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Journal of Biological Sciences

Year: 2003  |  Volume: 3  |  Issue: 3  |  Page No.: 371 - 375

Biological Activities of Extracts and two Flavonoids from Oroxylum indicum Vent. (Bignoniaceae)

Kawsar Uddin, Abu Sayeed, Anwarul Islam, Aziz Abdur Rahman, Seatara Khatun, G.R.M. Astaq Mohal Khan and Md. Golam Sadik

Abstract

The chromatographic examination of the ethyl acetate extract of a local plant Oroxylum indicum Vent. (Family: Bignoniaceae) has led to the isolation of two flavonoids: 2,5-dihydroxy-6,7-dimethoxy flavone (Compound 1) and 3, 7, 3`, 5`-tetramethoxy-4`-hydroxy flavone (Compound 2). The in vitro anti microbial activity of crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 was screened against fourteen (five Gram-positive and nine Gram-negative) pathogenic bacteria and seven pathogenic fungi using the disk diffusion method. The zones of inhibition produced by the crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 against pathogenic bacteria were found between 8-16, 8-19, 0-8, 9-18 and 9-21 mm, respectively and against pathogenic fungi, 8-20, 8-18, 9-15, 9-20 and 7-18 mm, respectively. The crude petroleum ether and ethyl acetate extracts and compound 1 and 2 showed mild to moderate activity against all bacteria and fungi, whereas the methanol extract showed little activity against bacteria but moderate activity against fungi. The minimum inhibitory concentration (MIC) of the compound 1 and 2 were measured against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae and the values were found to be between 64-128 μg/ml.

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