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Asian Journal of Plant Sciences

Year: 2003  |  Volume: 2  |  Issue: 17  |  Page No.: 1162 - 1165

An Antimicrobial Terpenoid from Caesalpinia pulcherrima Swartz.: Its Characterization, Antimicrobial and Cytotoxic Activities

A.K.M. Nasimul Islam, M. Abbas Ali, Abu Sayeed, Syed M. Abdus Salam, Anwarul Islam, Motiur Rahman, G.R.M. Astaq Mohal Khan and Seatara Khatun

Abstract

A terpenoid, 3-oxo-(20S, 24S)-epoxydammarane-19,25-diacetate (CP-1) isolated from the chloroform extract of barks of Caesalpinia pulcherrima was characterized on the basis of spectral data coupled with chemical evidence. The compound showed significant antibacterial activity against a number of pathogenic bacteria and prominent antifungal activity against a few fungi. The minimum inhibitory concentration (MIC) values against Bacillus cereus and Shigella dysenteriae were 16 μg ml-1 and 32 μg ml-1 respectively. The compound was found cytotoxic against brine shrimp and LC50 value was 8.41 μg ml-1. These findings suggested for further clinical trial.

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