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Journal of Biological Sciences
Year: 2002  |  Volume: 2  |  Issue: 1  |  Page No.: 46 - 48

Characterization and Biological Screening of a Triterpenoid from Nymphoides cristatum

Atiqur Rahaman, Abu Sayeed, Anwarul Islam, Dulaly Chowdhury, Golam Sadik and G. R. M. Astaq Mohal Khan    

Abstract: A triterpenoid, Bet-20(29)-en-3-ol-28-oic acid (1) was isolated from the ethyl acetate extract of Nymphoides cristatum (Roxb.) O.kuntze and its structure was elucidated on the basis of spectral evidences. This is the first report of isolation of this compound from this plant. The compound was screened for antimicrobial activity against a number of pathogenic bacteria and fungi and the cytotoxic activity by brine shrimp lethality bioassay. The test agent exhibited significant antimicrobial activity against most of the bacteria and fungi. The minimum inhibitory concentration (MIC) of the test agent determined against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella sonnei was found to be 64, 128, 64 and 32 μg/ml respectively. The compound also showed prominent cytotoxic activity. The LC50 (median lethal concentration) was 15.39 μg/ml. 50.

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