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Articles by A. Traore
Total Records ( 3 ) for A. Traore
  M. Lompo , I.P. Guissou , J. Dubois , J.P. Dehaye , S. Ouedraogo , A. Traore and N. Some
  In the present study, the antipyretic, analgesic and antiphospholipase A2 properties were investigated to explain the antiinflammatory effect of the stem barks aqueous extract. Yeast-induced hyperthermia in rat test was used to evaluate the antipyretic effect; writhing response induced by acetic acid in mice and rat tail-flick tests were used for antinociceptive effect. The effect of extract on the release of Arachidonic Acid (AA) and Oleic Acid (OA) in P388D1 cells was also investigated for the inhibitory activity of Phospholipase A2. It was found that 1 g kg-1 of extract inhibited significantly Yeast-induced hyperthermia about 100% only 1 h after administration. The extract inhibited significantly the writhing response. The ED50 of extract was 157.821 mg kg-1 wile ED50 for Aspirin was 65.09 mg kg-1. The reaction time to thermal stimuli was prolonged significantly (p<0.05) in dose-dependant manner in rats treated with 500 mg kg-1 (5.93 sec) and 750 mg kg-1 (7.08 sec) versus the control (4.32 sec) at 60 min. The extract inhibited the release of arachidonic (59.69%) and oleic acid (27.63%) and so inhibited Phospholipase A2 activity in P388D1 cells.
  A. Tibiri , J.T. Banzouzi , A. Traore , G.O Nacoulma , I.P. Guissou and B. Mbatchi
  This study was aimed to assess the possible toxic effects of Entada africana, a widely used African medicinal plant. The acute toxicity of the methanolic stem bark and leaf extracts of Entada africana Guill. and Perr., (Mimosaceae) was assessed on mice. It revealed an average toxicity with a LD50 of 146.7 and 249.9 mg kg-1 body weight for stem barks and leaves, respectively. The extracts showed no cytotoxicity against KB and Vero cells. Sub-chronic toxicity was assessed in rabbits, which received orally, daily for a month, a dose corresponding to 10% of the LD50. Compared to the control group this dose caused no significant (p>0.05) modification of haematological and biochemical parameters, total cholesterol, urea, creatinine and aspartate amino-transferase (AST). The extracts lowered serum glucose significantly (p<0.05) by 52% at first two weeks of treatment. The stem bark and leaf extracts showed temporary decrease (p<0.05) of Alanine amino transferase (ALT) by 26.1 and 39.1%, respectively. The stem bark extracts increased triglycerides significantly (p<0.01) by 108% at the end of last week of treatment. These investigations seemed to indicate the safety ob sub-chronic oral administration (up to 14.67 and 24.9 mg kg-1 body weight) of the methanolic extracts of Entada africana in rabbits.
  A. Gansane , S. Sanon , P.L. Ouattara , S. Hutter , E. Ollivier , N. Azas , A. Traore , A.S. Traore , I.P. Guissou , I. Nebie and B.S. Sirima
  The aim of the study is to investigate through traditional medicinal plants the possibility for discovery and development of new active and safe antimalarial drugs. For ecological reasons, bark of trunk of Zanthoxylum zanthoxyloides instead to roots was used by traditional healers in Burkina Faso to treat malaria or fever and recent study showed that crude alkaloid extract from the bark of trunk displayed good antiplasmodial activity. The bio-guided chromatographic fractionation of this crude alkaloid extract with solvents yielded 11 semi purified fractions which were tested for their antiplasmodial activity and cytotoxicity, respectively against Plasmodium falciparum W2 strains and K562S cells maintained in continuous culture and using flow cytometer. Non polar fractions 2, 3 and 4 displayed good antiplasmodial activity with IC50 ranging from 1.91 to 4.32 μg mL-1 and little toxicity with selectivity index ranging from 3.03 to 6.15. These data allow further investigations in terms of purification, isolation and development of new antiplasmodial compounds from these semi purified fractions and development of improved phytomedicine.
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