Toxicological Assessment of Methanolic Stem Bark and Leaf Extracts of Entada africana Guill. and Perr., Mimosaceae
This study was aimed to assess the possible toxic effects of Entada africana, a widely used African medicinal plant. The acute toxicity of the methanolic stem bark and leaf extracts of Entada africana Guill. and Perr., (Mimosaceae) was assessed on mice. It revealed an average toxicity with a LD50 of 146.7 and 249.9 mg kg-1 body weight for stem barks and leaves, respectively. The extracts showed no cytotoxicity against KB and Vero cells. Sub-chronic toxicity was assessed in rabbits, which received orally, daily for a month, a dose corresponding to 10% of the LD50. Compared to the control group this dose caused no significant (p>0.05) modification of haematological and biochemical parameters, total cholesterol, urea, creatinine and aspartate amino-transferase (AST). The extracts lowered serum glucose significantly (p<0.05) by 52% at first two weeks of treatment. The stem bark and leaf extracts showed temporary decrease (p<0.05) of Alanine amino transferase (ALT) by 26.1 and 39.1%, respectively. The stem bark extracts increased triglycerides significantly (p<0.01) by 108% at the end of last week of treatment. These investigations seemed to indicate the safety ob sub-chronic oral administration (up to 14.67 and 24.9 mg kg-1 body weight) of the methanolic extracts of Entada africana in rabbits.
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