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International Journal of Pharmacology
Year: 2006  |  Volume: 2  |  Issue: 5  |  Page No.: 557 - 562

Toxicological Effects of Sclerocarya birrea (A. Rich) Hochst (Anacardiaceae) and Psidium guajava L. (Myrtaceae) Leaf Extracts on Mice and Their Pharmacological Effects on Rat Duodenum

R.G. Belemtougri, A. Traore, Y. Ouedraogo, S.D. Sanou and L. Sawadogo    

Abstract: The aim of the present study was to investigate the toxicological effects of Sclerocarya birrea and Psidium guajava leaf extracts on mice and the antispasmodic effect on rat duodenum. The two plants extracts showed toxicological effects on mice in dose dependent manner. The antispasmodic effect was conducted as follow: In the first part of experiments, cumulative dose-response curve for Ach was obtained and then dose-response curves are repeated after addition of atropine and different doses of the extracts. In the second part, extracts were applied to the tissue after contraction with Ach. The extracts have exhibited an inhibitory effect on the dose-response curves induced by Ach on rat duodenum and significantly reduced the maximal response of Ach in a concentration-dependent manner. These results can partly justify the use of these plants in traditional medicine.

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