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International Journal of Pharmacology

Year: 2007  |  Volume: 3  |  Issue: 2  |  Page No.: 137 - 142

Mechanism of the Anti-inflammatory Activity of Khaya senegalensis A. Juss. (Meliaceae)

M. Lompo, I.P. Guissou, J. Dubois, J.P. Dehaye, S. Ouedraogo, A. Traore and N. Some

Abstract

In the present study, the antipyretic, analgesic and antiphospholipase A2 properties were investigated to explain the antiinflammatory effect of the stem barks aqueous extract. Yeast-induced hyperthermia in rat test was used to evaluate the antipyretic effect; writhing response induced by acetic acid in mice and rat tail-flick tests were used for antinociceptive effect. The effect of extract on the release of Arachidonic Acid (AA) and Oleic Acid (OA) in P388D1 cells was also investigated for the inhibitory activity of Phospholipase A2. It was found that 1 g kg-1 of extract inhibited significantly Yeast-induced hyperthermia about 100% only 1 h after administration. The extract inhibited significantly the writhing response. The ED50 of extract was 157.821 mg kg-1 wile ED50 for Aspirin was 65.09 mg kg-1. The reaction time to thermal stimuli was prolonged significantly (p<0.05) in dose-dependant manner in rats treated with 500 mg kg-1 (5.93 sec) and 750 mg kg-1 (7.08 sec) versus the control (4.32 sec) at 60 min. The extract inhibited the release of arachidonic (59.69%) and oleic acid (27.63%) and so inhibited Phospholipase A2 activity in P388D1 cells.

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