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Articles by A.M. Musa
Total Records ( 8 ) for A.M. Musa
  K.M. Elamin , M.A. Elkhairey , A.O. Bakhiet , H.B. Ahmed and A.M. Musa
  The experiment was conducted to evaluate the effects of feeding Sweet potato on Carcass and non-carcass traits of local rabbits in Sudan. Twenty seven weaner rabbits at average weight of 400-500 g and average age of 45 days were used. Animals were randomly divided into three groups. Each group was fed a separate ration formulated either on Lucerne (Barseem) (ration A), sweet potato (Ipomoea batatas) (ration B) or Clitoria ternate (ration C) for a whole month. Treatment effect was not significant (p>0.05) in all parameters. Group C (C. ternate) performed the highest values for fore leg and shoulder (50.67±7.02) while group B (I. batatas) showed the highest values for loin (118.33±9.29), ribs (59.24±0.46) and hind leg and rump (98.29±2.90). Group B (Sweet potato) recorded the highest values for all parameters as percentages, group C (C. ternate) ranked second in all parameters and the control group conversely gave the lowest values.
  A.B. Aliyu , M.A. Ibrahim , A.M. Musa , T. Bulus and A.O. Oyewale
  Leaf extract and fractions of Vernonia blumeoides were evaluated for total phenolics content (Folin-Ciocalteu method), free radical scavenging activity (1, 1-diphenyl-2-picrylhydrazyl radical assay), total antioxidant capacity (Phosphomolybdate assay) and ferric reducing power. The results of the phenolics content expressed in mg/100 g of Gallic Acid Equivalent (GAE) showed that the n-butanol fraction has significantly (p<0.05) higher phenolics content (410±0.8) than the chloroform fraction and ethanol extract. The radical scavenging activity of the extract and solvent fractions displayed strong concentration dependent activity. But it was also observed that the ethyl acetate fraction showed highest activity in all concentration tested ranging from 70.56 to 99.04%. However, the total antioxidant capacity (mg g-1 ascorbic acid) showed that n-butanol fraction has the highest capacity (60.0 mg g-1). The results also showed that the n-butanol extract has strongest reducing ability (2.105±0.109 nm) at higher concentration which is comparable to that of Gallic acid at all the concentrations tested. Phytochemical screening on the extracts revealed the presence of flavonoids, saponins and tannins. The results suggest that the plant especially the n-butanol and ethyl acetate fractions are very rich in antioxidant compounds worthy of further investigations.
  A.M. Musa , A.H. Yaro , H. Usman , M.G. Magaji and M. Habu
  The phytochemical constituents and some neuropharmacological activity of the methanolic leaf extract of Cissus cornifolia (Bak.) Planch [Family: Vitaceae] was evaluated in mice employing various models. The preliminary qualitative phytochemical analysis carried out on the methanolic leaf extract of Cissus cornifolia revealed the presence of alkaloids, flavonoids, saponins, steroids/terpenoids, stilbenoids and tannins. The neuropharmacological effects of the methanolic leaf extract of Cissus cornifolia on CNS were evaluated using diazepam sleeping time, exploratory behaviour (head dip tests), motor coordination and acute toxicity studies in mice. The extract at tested doses (10, 20 40 mg kg-1 body weight i.p.) produced reduction in exploratory behaviour (head dip test), beam walking assay (foot slips) and potentiate the diazepam-induced sleep in mice; the LD50 was found to be 775.0 mg kg-1 body weight i.p. in mice. These results corroborates with the traditional usage of this plant as a remedy against mental derangement as confirmed by the sedative activity expressed by the extract.
  B.A.H. Al- Nabehi , H. Al- Shamahy , W.S.E. Saeed , A.M. Musa , A.M. El Hassan and E.A.G. Khalil
  Viral hepatitis is an acute or chronic neglected disease that affects predominantly the liver. This study aimed to determine the sero prevalence and risk factors for viral hepatitis and HCV genotypes in urban areas of Yemen. In a prospective, cross-sectional, analytical and community-based study and following informed consent, 501 volunteers were randomly recruited. Demographic and clinical data was collected. Screening for HBV, HDV and HCV was carried out using ELISA. HBV/HCV viral loads and HCV genotyping were carried out using COBAS® TaqMan®48 Analyzer (Roche Diagnostics Gmbh, Germany). The mean age of study population was 25.9±10.6 years with a male: female ratio of 1. HBV sero prevalence was similar in Sana'a, Taiz and Aden (p = 0.2). Evidence of past HBV infection was significantly high in Aden and Taiz (14.1 and 18.8%, respectively) compared to Sana’a (5.4%) (p = 0.002). HBV DNA Viral loads were widely variable (1350 and 6320 copies mL–1). HCV sero prevalence was low and not significantly different in the study cities (p = 0.4). HCV Viral loads were widely variable between samples (657300-1630000 copies mL–1). HCV Genotypes 4 and 1a were the most predominant genotypes. Blood transfusion (19%), renal dialysis (18.6%), history of cupping (18.1%), surgical operation (17.4%) and dental treatment (15.4%) were the most common risk factors for HBV and HCV sero reactivity. In conclusion, HBV sero prevalence is variable among different geographical areas in Yemen. Past exposure to HBV is high. Blood transfusion and contaminated surgical instruments are important infection risks for viral hepatitis. HCV genotypes 4 and 1a are the most prevalent.
  Y.M. Sani , A.M. Musa , A.H. Yaro , M.B. Sani , A. Amoley and M.G. Magaji
  Cissus polyantha is used in African traditional medicine is the management of pain and inflammatory conditions. This study was therefore designed to evaluate the analgesic and anti-inflammatory activities of the methanol extract of the leaf of Cissus polyantha, as well as to establish the class of phytochemical constituents present in the extract. The analgesic effect was studied using acetic acid-induced writhing and hot plate tests in mice, while anti-inflammatory effect was investigated using carrageenan-induced hind paw oedema in rats. The results of the study showed that the extract significantly (50, 100, 200 mg kg-1) (p<0.001) and dose-dependently inhibited acetic acid-induced writhing. The extract at dose of 100 mg kg-1 increased the mean pain responses by 69.25% compared to control. At the end of third hour after carrageenan administration, the various doses of the extract offered 65.67, 70.15 and 67.16% inhibition of hind paw oedema, respectively. These effects were more remarkable than those produced by ketoprofen (63.8%). Preliminary phytochemical screening revealed the presence of steroids, flavonoids, saponins, tannins and anthraquinones. The intraperitoneal mean lethal dose (LD50) of the extract in mice was estimated to be 774.6 mg kg-1. The findings of this study showed that the methanol leaf extract of Cissus polyantha contains some pharmacologically active principle(s) with analgesic and anti-inflammatory activities and lend credence of the ethnomedical use of the plant in the management of pain and inflammatory conditions.
  M.G. Magaji , Y. Yakubu , R.A. Magaji , A.M. Musa , A.H. Yaro and I.M. Hussaini
  Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg-1) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice. The CNS depressant effect was also evaluated using ketamine-induced sleep test mice. The extract at the highest dose tested (100 mg kg-1) significantly reduced the apomorphine (1 mg kg-1)-induced stereotypic climbing behavior after 30 min. Similarly, haloperidol (2 mg kg-1), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, haloperidol (2 mg kg-1) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total ketamine-induced sleep duration at doses of 50 and 100 mg kg-1. These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of mental illness.
  A.M. Musa , G. Abbas , A.B. Aliyu , M.S. Abdullahi and I.N. Akpulu
  Antimicrobial activities of the crude methanol extract as well as the n-butanol and residual aqueous fractions from the aerial part of Indigofera conferta used in traditional medicine to treat infected wound were investigated using disc diffusion and broth dilution techniques. The extract and the fractions were tested against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Candida albicans using Ampiclox as standard antibiotic. The crude methanol extract and the aqueous fraction exhibited activity against all the organisms tested (zones of inhibition 16-34 and 14-31 mm, respectively). The n-butanol fraction showed activity on Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa only (zones of inhibition 14-25 mm). Phytochemical screening on crude extract revealed the presence of tannins, flavonoids and steroids. This study showed that the leaves of Indigofera conferta contains active compounds and its antimicrobial activity justifies its use in traditional medicine.
  A.B. Aliyu , A.M. Musa , M.S. Sallau and A.O. Oyewale
  Biochemical studies with a view to assess the nutritional potentials of Anisopus mannii were carried out by evaluating the proximate composition, mineral elements and anti-nutritional content of the plant. The results showed that the total oxalates, free cyanides, tannins and total cyanides were found to be present at 0.70 ± 0.5, 6.50 ± 0.41, 10.55 ± 0.01 and 12.41 ± 7.19%, respectively. However, concentration of phytate was very low (0.017 ± 0.00%). Proximate compositions of the plant showed a rich source of crude protein (8.40 ± 0.17%), fats (8.67 ± 0.63%), carbohydrates (72.57 ± 0.68%) and total ash (10.36 ± 0.22%). The plant was also found to contain the following essential minerals: potassium (1700 mg/100 g), calcium (1280 mg/100 g), iron (156 mg/100 g), vanadium (102 mg/100 g), chromium (53.90 mg/100 g), zinc (0.874 mg/100 g), copper (1.43 mg/100 g) and manganese (36.60 mg/100 g). The results of this research indicated that Anisopus mannii has nutritional qualities that could provide the users with additional nutrients for enhanced curative process of ill health.
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