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Articles by S. Ibrahim
Total Records ( 7 ) for S. Ibrahim
  J. Levita , D. Rahayu , N.M. Saptarini , A. Nawawi , A. Mutalib and S. Ibrahim
  The aim of this work was to explore the bioactivity andrographolide, a major labdane diterpenoidal constituent of Andrographis paniculata, especially its influence on the expression of certain protein in LPS-induced human leucocyte cells. Human leucocyte cells were isolated from human whole blood and preincubated with andrographolide (25-200 μM) for 15 min. The preincubated cells were treated with lipopolysaccharide for 1 h afterwards. The method used in this work was SDS-PAGE, a polyacrylamide gel electrophoresis with a sodium dodecyl sulfate-containing buffer. Andrographolide inhibited the expression of certain protein which molecular weight was 36 kDa and identified as carbonic anhydrase. Since this enzyme produces and uses protons and bicarbonate ions, inhibition of this enzyme might lead to a decrease of acid production in the stomach and mild alkalosis.
  W.L. Willis , O.S. Isikhuemhen , S. Ibrahim , K. King , R. Minor and E.I. Ohimain
  An experiment was conducted to investigate the effects of Fungus (Lentinula edodes) Myceliated Grain (FMG) supplementation on production performance, leukocyte levels and growth of Bifidobacteria and Salmonella populations in broiler chickens. A total of 240 broiler chickens were kept in floor pens and fed a corn and soybean meal based diet with added fungus myceliated grain at 0% (control), 1%, 5% and 10%. The four experimental feeding conditions were replicated six times with ten chicks per replicate. Parameters measured were male and female live body weight, carcass yield, bursa and spleen weights, Salmonella sp. and Bifidobacteria fecal populations and blood differential cell counts. The results from this study revealed no significant differences between treatments in male or female body weight, carcass yield, spleen or bursa weight. Significantly (p<0.05) higher Bifidobacteria populations were observed in the 5 and 10% (FMG) treatments. In contrast, a lower Salmonella fecal population (log value) was observed in the 10% (FMG) treatment. The heterophil percent was significantly (p<0.05) higher utilizing the 1% (FMG) supplements with lower lymphocyte percentages compared with other treatments. The results from this study indicate that fungus myceliated grain tested at all levels of inclusion did not adversely affect production performance and at higher levels led to increased Bifidobacteria and reduction in Salmonella. It is concluded that this feedstuff having beneficial properties from the fungal species is suitable as a broiler chicken food supplement.
  I.J. Mbuko , W.I. Musa , S. Ibrahim , L. Sa`idu , P.A. Abdu , S.B. Oladele and H.M. Kazeem
  A five year retrospective study (2004-2008) of the prevalence of Gumboro disease (infectious bursal disease, IBD) and other poultry disease diagnosed at the poultry unit of the Ahmadu Bello University Veterinary Teaching Hospital (ABUVTH), Zaria, Kaduna Nigeria was conducted. A prevalence of 7.26% (107 cases) was recorded out of 1473 cases of poultry disease. Gumboro disease occurred throughout the year in Zaria with a high incidence during the festival periods (July-September, October-December and January-March). The outbreaks of IBD were observed to be 1.3 times more likely to occur in pre-rainy season (April-June). Improved breeds of chickens were 5.8 times more likely to suffer from IBD than free range local chickens with broilers being 5.7 times more likely to suffer from the disease than other type of birds followed by layers kept together with cockerels. The prevalence of IBD is influenced by age of birds with an increase in the likelihood of IBD occurring within the age range of 3-5 week. Birds at 5 weeks old were at highest risk. Chickens with one vaccination history against IBD were 8.2 times more likely to suffer from the disease compared to non-vaccinated chickens. This study recommends that poultry farmers should be encourage to improve on farm biosecurity and ensure that their birds are vaccinated at least twice, before 3 and 5 weeks of age (at 1 and 3 or 2 and 4 weeks of age).
  H.I. Ragab , K.A. Abdel Ati , C. Kijora and S. Ibrahim
  L. purpureus is considered to substitute some of conventional plant protein sources in poultry diets. In 12 weeks feeding trial the processed L. purpureus seeds were investigated for its impacts on laying performance, egg quality and serum constituents of Hisex White hens. Diets contain 0, 5, 10, 15 and 20% L. purpureus were allotted randomly following completely randomized design to 25 units of three birds each. Hen day egg production, egg weight, egg mass, FCR and weight gains were significantly (p<0.01) high up to 10% L. purpureus. Shell percentage and thickness were significantly (p<0.05) high in control and 20% L. purpureus groups. 15 and 20% L. purpureus dietary groups were of high egg albumin index and percentage. The utmost (p<0.05) yolk index and percentage were shown in 15 and 10% L. purpureus groups, respectively. Comparable high Haugh units were shown in different treatment groups. 15% L. purpureus groups, recorded significant (p<0.01) high serum total protein and globulin. All L. purpureus treatment groups were of significant (p<0.05) low serum albumin. Serum glucose was significantly (p<0.01) lowered in L. purpureus groups, while serum cholesterol was insignificantly (p>0.05) reduced due to L. purpureus inclusion. The 20 and 10% L. purpureus groups when compared to control were found of low serum P and Ca, respectively. In conclusion, up to 10% dietary inclusion of L. purpureus is appropriate to provide similar laying performance as the standard layers diet.
  W.L. Willis , D.C. Wall , O.S. Isikhuemhen , S. Ibrahim , R.C. Minor , J. Jackson , S.L. Hurley and F. Anike
  An experiment was conducted to evaluate the feeding of four mushrooms separate and combined via Fungus Myceliated Grain (FMG) on broiler chicken performance after an Eimeria challenge at 14 days of age. Male broilers (n-180) were randomly allocated to 1 of 12 treatments, replicated 3 times with 5 chicks each in a battery cage system for 28 days as follows: 1) Control-1 (no FMG, unchallenged), 2) Control-2 (no FMG, challenged), 3) Shiitake (S) 5% FMG, (unchallenged), 4) Shiitake (S) 5% FMG, (challenged), 5) Reishi (R) 5% FMG, (unchallenged), 6) Reishi (R) 5% FMG, (challenged), 7) Cordyceps (C) 5% FMG, (unchallenged), 8) Cordyceps (C) 5% FMG, (challenged), 9) Oyster (O) 5% FMG, (unchallenged), 10) Oyster (O) 5% FMG, (challenged), 11) S+R+C+O 5% FMG, (unchallenged) and 12) S+R+C+O 5% FMG, (challenged). Live weight and feed intake were measured at day 7, 14, 21, 28 and oocyst excretion, mortality and bursa weights at day 28. Coccidiosis infection induced depressed body weights in challenged birds at 21 and 28 days. Eimeria challenged birds in treatment four given Shiitake 5% FMG had body weights that were significantly higher than the other challenged birds at 21 days. The 28-day weight did not differ from each other in the challenged and unchallenged except for treatment seven (Cordyceps-unchallenged) which was significantly lower. While Eimeria counts at day 28 showed significant (p<0.05) differences amongst challenged groups, significant differences were not found in the unchallenged treatment groups. There were significant (p<0.05) differences in Eimeria counts and bursa weights between challenged and unchallenged birds at day 28. The results from this study demonstrate that Shiitake was superior and Cordyceps, at the 5% inclusion level, depressed body weight in birds whether they were challenged or unchallenged but data suggest that Cordyceps may reduce oocyst shedding.
  M.R. Suwitono , R.E. Kartasasmita , J.S. Pamudji and S. Ibrahim
  Thiols such as N-acetylcystein (NAC) are used to replenish glutathione (GSH) level, with regard to their function in the maintenance of cellular reduction-oxidation balance and control of oxidative stress. Thiols play a role in the reductive metabolism of nitrates to NO, an important signaling molecule in the cardiovascular system as well as other systems throughout the body. This study aimed to evaluate the influence of NAC on decomposition of different organic nitrate esters according to its potential i.e., pentaerythrityl tetranitrate (PETN) and isosorbide dinitrate (ISDN). The results showed that NAC gives a rapid and significant decrease of PETN and ISDN during the incubation period. During the experiment, about 85% of PETN were decomposed, while the decomposition of ISDN was about 20%. Detection of nitrite and elucidation of disulphide bond of NAC gives evidence that confirms the presence of reactions.
  S. Mohan , A. Bustamam , S. Ibrahim , A. S. Al-Zubairi and M. Aspollah
  Typhonium flagelliforme (Lodd.) Blume, commonly known as rodent tuber in Malaysia, is one of the widely used alternative medicines in cancer therapy by South East Asian population. Intake of this plant is common among patients with malignancies especially Leukaemia, breast and cervical cancer; however no data available regarding the possible direct effect of T. flagelliforme in these cancers. The purpose of the present study was to investigate the potential in vitro cytotoxic effect of leaves and tubers of T. flagelliforme extracts against human T4-lymphoblastoid cell line CEM-ss. Among the 8 extracts Dichloromethane and Ethyl acetate extracts of T. flagelliforme demonstrated significant anti proliferative effect with a marked level for both leaves (10.8 and 5.8 μg mL-1) and tuber (6.5 and 8.2 μg mL-1), against CEM-ss cells. Considering all the results collectively T. flagelliforme appears to be a promising plant demonstrating anti cancer activity, that requires further investigation.
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