Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Pakistan Journal of Biological Sciences
Year: 2005  |  Volume: 8  |  Issue: 2  |  Page No.: 255 - 258

Effect of Oral Administration of Aqueous Extract of Khaya senegalensis Stem Bark on Phenylhydrazine-induced Anaemia in Rats

F.S. Sanni, S. Ibrahim, K.A.N. Esievo and S. Sanni    

Abstract: The anti-anaemic effect of Khaya senegalensis stem bark on phenylhydrazine-induced anaemia was carried out in rats. Induction of anaemia was conducted using phenylhydrazine hydrochloride at a dose of 750 mg kg-1 body weight. In vivo investigation showed that oral daily dose of 300 mg kg-1 body weight of the bark aqueous extract of K. senegalensis in rats administered simultaneously with the phenylhydrazine produced significant (p<0.05) anti-anaemic effect probably by protecting the red blood cells against destruction by phenylhydrazine. However, the same oral dose did not show any significant curative effect (p>0.05) after the induction of anaemia using phyenylhdrazine hydrochloride. The phytochemical screening of the aqueous extract of the stem bark of K. senegalensis indicate the presence of carbohydrate, saponin, glycosides and tannins. Also present are important mineral elements necessary for the development and functioning of the body. These include calcium, magnesium, zinc, iron, copper, potassium, and sodium. This study showed that Khaya senegalensis has an anti-anaemic effect.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility