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Journal of Medical Sciences
Year: 2005  |  Volume: 5  |  Issue: 4  |  Page No.: 280 - 283

Effect of Guiera senegalensis Leaf Extract on Some Echis carinatus Venom Enzymes

A.B. Sallau, G.C. Njoku, A.R. Olabisi, A.U. Wurochekke, A.A. Abdulkadir, Shehu Isah, M.S. Abubakar and S. Ibrahim    

Abstract: Aqueous extract of Guiera senegalensis leaves was investigated for the inhibitory action on the activity of crude phospholipase and metalloprotease enzymes from Echis carinatus venom. Both enzymes were inhibited by the extract in a dose dependent fashion. Double reciprocal plots of the initial velocity data of the inhibition by the extract revealed a non-competitive pattern of inhibition for the metalloprotease and a competitive one for the phospholipase. Extrapolated Ki values were found to be 11.9 and 90 μg mL-1 for the metalloprotease and phospholipase, respectively.

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