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Articles by M. Iqbal Choudhary
Total Records ( 5 ) for M. Iqbal Choudhary
  Atta-ur- Rahman , Atia-tul- Wahab , S. Zia Sultani , Sarfraz A. Nawaz and M. Iqbal Choudhary
  A new bisbenzylisoquinoline alkaloid, 1,2-dihydrokurramine (1), and four known bisbenzylisoquinoline alkaloids 2-5, along with a morphinan alkaloid 6 were isolated from Cocculus pendulus. The structures for these compounds were deduced by spectroscopic methods. All bisbenzylisoquinoline alkaloids showed inhibitory activities against acetyl- and butyrylcholinesterases.
  Saeedan Begum , M. Iqbal Choudhary and Khalid M. Khan
  Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.
  M. Iqbal Choudhary , M. Atif and Atta-Ur- Rahman
  Transformation of lynestrenol (19-nor-17α-pregn-4-en-20-yn-17β-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17α-pregn-4-en-20-yn-3-one-10β,17β-diol (2), 19-nor-17α-pregn-4-en-20-yn-3-one-6β,17β-diol (3), and 19-nor-17α-pregn-4-en-20-yn-3β,6β,17β-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques.
  Syeda Farina Asghar , Habib-ur- Rehman , Atta-ur- Rahman and M. Iqbal Choudhary
  Phytochemical investigations on the methanol extract of Iris germanica resulted in the isolation of a new benzene derivative, 2´-methyl-6´-hydroxy cyclohexenyl-3-methyl-1-acetophenone ether (1). Further, another known benzene derivative, isopenol (2), also afforded two known isoflavones, irisolone (3) and irisolidone (4). The structure of the new compound was determined on the basis of spectroscopic data, including 2D-NMR experiments, while the known compounds were identified on the basis of their spectral data and existing literature evidence. The comparison of the spectral data of the irisolidone (3) with that reported for the molecule led us to revise some of the reported 1H-NMR chemical shift assignments.
  Ilkay Orhan , Betul Demirci , Iman Omar , Huma Siddiqui , Erdal Kaya , M. Iqbal Choudhary , Gulay Ecevit-GenC , Neriman ozhatay , Bilge Sener and K. Husnu Can Baser
  Essential oil compositions and antioxidant potentials of fourteen ethanol (75%) root extracts prepared from twelve taxa of the genus Paeonia (Paeoniaceae), including P. arietina Anders., P. daurica Andrews, P. xkayae N. Özhatay, P. kesrouanensis Thiéb., P. mascula (L.) Miller subsp. arasicola G. Kaynak, ö. Yilmaz & R. Daşkin, P. mascula (L.) Miller subsp. bodurii N. Özhatay, P. cf. mascula L. (Mill.) subsp. mascula (two samples from central and northeastern Anatolia), P. cf. officinalis Retz., P. peregrina Miller (two samples from western and northwestern Anatolia), P. tenuifolia L., P. turcica Davis & Cullen, and P. wittmanniana Hartwiss ex Lindl. were assessed. The chromosome numbers of the root tips of the species were examined using chromosome staining technique with Shiff’s reagent under Leitz microscope. The essential oils of the roots of the Paeonia species were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) and the major components were identified as salicylaldehyde (10%–94.4%), cis-myrtanal (5.5%–59.7%), and methyl salicylate (2%–52.2%). Antioxidant potentials were tested against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) radicals using propyl gallate and rutin as the references. Total phenolic contents of the ethanol extracts were determined using Folin-Ciocalteau’s method. The extracts exerted moderate NO scavenger effect and displayed insignificant DPPH radical scavenger activity at 500 μg mL−1. On the other hand, P. daurica, P. tenuifolia and P. cf. mascula subsp. mascula are diploids with 2n=10, while other nine taxa are tetraploids with 2n = 20.
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