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Natural Product Research Part A

Year: 2010  |  Volume: 24  |  Issue: 1  |  Page No.: 1 - 6

Oxidation of lynestrenol by the fungus Cunninghamella elegans

M. Iqbal Choudhary, M. Atif and Atta-Ur- Rahman

Abstract

Transformation of lynestrenol (19-nor-17α-pregn-4-en-20-yn-17β-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17α-pregn-4-en-20-yn-3-one-10β,17β-diol (2), 19-nor-17α-pregn-4-en-20-yn-3-one-6β,17β-diol (3), and 19-nor-17α-pregn-4-en-20-yn-3β,6β,17β-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques.

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