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Articles by A.Y. Coulibaly
Total Records ( 5 ) for A.Y. Coulibaly
  A.Y. Coulibaly , J.H. Bationo , Fatouma Mohamed Abdoul-Latif , Bakasso Sahabi and M. Kiendrebeogo
  Background and objectives: Scoparia dulcis is a medicinal herb traditionally used to relieve dementia disorders in Burkina Faso. A female Wistar rats model was used against hydroacetonic extract of Scoparia dulcis to assess the effect of neuroprotective, hepatoprotective and renoprotective. Materials and Methods: The rats were divided into 5 groups with 6 animals/group. Carboxymethyl cellulose (CMC, 0.5%) was used as vehicle to treat the animals by oral route with silymarin or the plant extract. Seven days later, they were intoxicated by intra-peritoneal injection of carbon tetrachloride (2 mL kg1) for 24 h. Then blood, brain, kidney and liver were taken for further analysis. Results: It resulted on a neuroprotective effect noted by an increase in acetylcholinesterase level, a hepatoprotective effect was also registered with a significant decrease in triglycerides, cholesterol, alanine amino-transferase (ALT), aspartate amino-transferase (AST), superoxide dismutase (SOD) and malondialdehyde (MDA). The renoprotective potential was marked by a decrease of urea, uric acid and creatinine. Conclusions: Scoparia dulcis can be a suitable candidate for investigation of neuroprotective agents.
  P.A.E.D. Sombie , A. Hilou , A.Y. Coulibaly , A. Tibiri , M. Kiendrebeogo and O.G. Nacoulma
  The purpose of the present study was to investigate the protective effects of the extracts against H2O2-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL-1). Under the oxidative action of H2O2, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.
  N.T.R. Meda , A. Lamien-Meda , M. Kiendrebeogo , C.E. Lamien , A.Y. Coulibaly , J. Millogo-Rasolodimby and O.G. Nacoulma
  The present study aimed to test the validity of Balanites aegyptiaca remedies used for the treatment of rheumatisms and mental disorders by examining the antioxidant, xanthine oxidase and acetylcholinesterase inhibitory activities of galls and leaves extracts and fractions. The total phenolics and flavonoids were measured using Folin-Ciocalteu and AlCl3 reagents, respectively. Two methods i.e., FRAP and ABTS were used to estimate the total antioxidant capacity of the plant materials. The FRAP and ABTS antioxidant activities showed that among all extracts and fractions tested, the best antioxidant activities were found with the galls dichloromethane and the leaves ethyl acetate fractions. The antioxidant activities did correlated significantly with the total phenolic and flavonoid contents. The study also showed that B. aegyptiaca galls and leaves fractions exhibited a moderate xanthine oxidase inhibitory activity comparatively to the acetylcholinesterase which was weakly inhibited by the tested extracts and fractions.
  K. Konate , A. Souza , A.Y. Coulibaly , N.T.R. Meda , M. Kiendrebeogo , A. Lamien-Meda , J. Millogo-Rasolodimby , M. Lamidi and O.G. Nacoulma
  In this study polyphenol content, antioxidant activity, lipoxygenase (LOX) and Xanthine Oxidase (XO) inhibitory effects of n-hexane, dichloromethane, ethyl acetate and n-butanol fractions of aqueous acetone extracts from S. alba L., S. acuta Burn f. and Cienfuegosia digitata Cav. were investigated. The total phenolics, flavonoids, flavonols and total tannins were determined by spectrophotometric methods using Folin-ciocalteu, AlCl3 reagents and tannic acid, respectively. The antioxidant potential was evaluated using three methods: inhibition of free radical 2,2-diphenyl-1-picrylhydramzyl (DPPH), ABTS radical cation decolorization assay and Iron (III) to iron (II) reduction activity (FRAP). For enzymatic activity, lipoxygenase and xanthine oxidase inhibitory activities were used. This study shows a relationship between polyphenol contents, antioxidant and enzymatic activities. Present results showed that ethyl acetate and dichloromethane fractions elicit the highest polyphenol content, antioxidant and enzymatic activities.
  P.A.E.D. Sombie , A. Hilou , C. Mounier , A.Y. Coulibaly , M. Kiendrebeogo , J.F. Millogo and O.G. Nacoulma
  The galls of Guiera senegalensis J.F. Gmel (Combretaceae) are used in Burkina Faso traditional medicine to treat some microbial and metabolic diseases such as malaria, dysentery, diabetes and hypertension. The purpose of the present study was to investigate the phytochemical analysis, the antioxidant and anti-inflammatory inhibitory activities from the galls of Guiera Senegalensis. Phytochemical assay was conducted with following standard protocols. The method of DPPH, FRAP, β-carotene assay, anti-lipid peroxidation (according to the thiobarbituric acid method) studies in vitro were employed to assess the antioxidant efficacy. The xanthine oxidase and lipoxygenase inhibition properties of extracts and fractions were also evaluated to assess the anti-inflammatory activity from galls of Guiera senegalensis. Galls extracts of G senegalensis are rich in totals polyphenol and in totals flavonoid content. The hydroacetonic extract showed the most potent antioxidant activity in FRAP method (10.88±0.86 mmol AEAC g-1) and anti-lipid peroxidation activity (75.06±2.42%) at a concentration of 1.25 mg mL-1. The water fraction of hydroacetonic extract showed the most potent antioxidant activity (6.012±0.13 mmol AEAC g-1 ) in the DPPH radical scavenging method and butanol fraction of hydroacetonic extract in the β-carotene bleaching method (59.00±3.27%) at a concentration of 100 μg mL-1. The highest antioxidant activity can be positively correlated with the highest total phenolics content and also with the highest anti-inflammatory activity of the tested extract/fraction. The present study thus provides a scientific rationale for the traditional use of this plant product to the treatment of metabolic diseases.
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