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Journal of Pharmacology and Toxicology
Year: 2011  |  Volume: 6  |  Issue: 4  |  Page No.: 361 - 370

Brain Protective and Erythrocytes Hemolysis Inhibition Potentials from Galls of Guiera senegalensis J.F. Gmel (Combretaceae)

P.A.E.D. Sombie, A. Hilou, A.Y. Coulibaly, A. Tibiri, M. Kiendrebeogo and O.G. Nacoulma    

Abstract: The purpose of the present study was to investigate the protective effects of the extracts against H2O2-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL-1). Under the oxidative action of H2O2, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.

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