Abstract: The purpose of the present study was to investigate the protective effects of the extracts against H₂O₂-induced hemolysis of erythrocytes and the neuroprotective potential from galls of Guiera senegalensis. Ethyl acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05) inhibited lipid peroxidation in rat’s brain homogenate in vitro (37.79±0.93% at 1.25 mg mL^-1) when compared to the gallic acid and quercetin used as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07% at 100 μg mL^-1). Under the oxidative action of H₂O₂, the extracts from galls of G. senegalensis showed significant protection of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE) contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg of extract) content. The erythrocytes hemolysis inhibitory property from galls of G. senegalensis seems to be related weakly to its total tannin content (p<0.05). The present study thus suggested that the galls from G. senegalensis could be used as a new potential source of natural neuro-protective and antioxidant components.