Asian Science
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Abstract: The purpose of the present study was to investigate the protective effects
of the extracts against H2O2-induced hemolysis of erythrocytes
and the neuroprotective potential from galls of Guiera senegalensis. Ethyl
acetate fraction of aqueous decoction extract (EAF/ADE) significantly (p<0.05)
inhibited lipid peroxidation in rats brain homogenate in vitro (37.79±0.93%
at 1.25 mg mL-1) when compared to the gallic acid and quercetin used
as positive controls and has the best anti-acetylcholinesterase activity (64.02±4.07%
at 100 μg mL-1). Under the oxidative action of H2O2,
the extracts from galls of G. senegalensis showed significant protection
of the erythrocyte membrane from hemolysis. The Aqueous Decoction Extract (ADE)
contains the highest amount of total tannin (25.3±1.55 mg TAE/100 mg
of extract) content. The erythrocytes hemolysis inhibitory property from galls
of G. senegalensis seems to be related weakly to its total tannin content
(p<0.05). The present study thus suggested that the galls from G. senegalensis
could be used as a new potential source of natural neuro-protective and antioxidant
components.