Abstract: The increasing incidence of microorganisms becoming resistant to antibiotics has continuously become a scientific community concern. Many scientists around the world are performing research on plants to be able to discover possible antimicrobial compounds. To date, many plant secondary compounds are known to have diverse biological activities. These may include antibacterial, antifungal and anticancer activities. In this regard, many scientists want to isolate, purify and identify plant secondary metabolites. The aim of this study is to provide recent insights on the different secondary metabolites class and the experimental evidences of antibacterial activities against many different pathogens.