Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2012 | Volume: 6 | Issue: 5 | Page No.: 370-382
DOI: 10.3923/rjmp.2012.370.382
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Antimicrobial Activity and Safety of two Medicinal Plants Traditionally used in Bomet District of Kenya
R.K. Korir, C. Mutai, C. Kiiyukia and C. Bii

Abstract:
Indigenous rural communities in the tropics manage microbial diseases using herbal concoctions. The efficacy and safety of most of the herbal preparations have not been proven scientifically. Extracts from two selected plant species were evaluated for in vitro antimicrobial activities and toxicity. Extraction was done using hexane, dichloromethane, methanol and water. Hexane extracts of Senna didymobotrya was active against Microsporum gypseum with 16.0 mm inhibition zone diameters and no activity against other test isolates. Dichloromethane extracts had good activities against Trichophyton mentagrophyte and Microsporum gypseum with 18.0 and 15.0 mm inhibition zones, respectively. Minimum inhibition concentration of Cyathula polycephala extracts against bacterial isolates ranged from 25.0 to 3.124 mg mL-1. Methanol extracts of C. polycephala had a CC50 of 100.0%. The water extracts recorded CC50 of 23.75 and 31.56% at 1000 and 100 mg mL-1 concentration, respectively. The methanol extracts recorded a CC50 of 99.34 and 100.0% at 1000 and 100 mg mL-1 concentration, respectively. The DCM extract of S. didymobotrya was very toxic at 5000 mg kg-1 and killed 80% of mice. In both the cell and acute toxicity, it was observed that extracts at high concentration and at a high dose tend to be toxic. Most extracts were active against a wide range of bacteria than fungi.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Antimicrobial Activity of Plant Secondary Metabolites: A Review
  •    Antibacterial Activity of Methanolic Extract of Whole Body Tissue and Ethylene Diamine Tetra Acetate Extract of Cuttlebone of Sepiella inermis (Orbigny, 1848)
How to cite this article:

R.K. Korir, C. Mutai, C. Kiiyukia and C. Bii, 2012. Antimicrobial Activity and Safety of two Medicinal Plants Traditionally used in Bomet District of Kenya. Research Journal of Medicinal Plants, 6: 370-382.

DOI: 10.3923/rjmp.2012.370.382

URL: https://scialert.net/abstract/?doi=rjmp.2012.370.382

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

       

       

Curve Bottom