Abstract: The aim of this research is to determine the protective efficacy of Triphala in adjuvant-induced arthritis with respect to lipid peroxidation, antioxidant status and inflammatory mediator tumour necrosis factor-alpha (TNF-α). Arthritis was induced by intradermal injection of Complete Freund’s Adjuvant (0.1 mL) into the right hind paw of Swiss albino mice. Triphala (1000 mg kg-1 day-1) and Indomethacin (3 mg kg-1 day-1) were orally administered for 8 days (from 11th to 18th day) after adjuvant injection. The levels of lipid peroxides, enzymic and non-enzymic antioxidants and tumour necrosis factor-α were measured in blood and spleen of control and arthritic animals. In arthritic animals, the lipid peroxidation and tumour necrosis factor-α were found increased, whereas a decrease in antioxidant levels was observed. These observed alterations were significantly modulated to near normal levels by oral administration of Triphala (1000 mg kg-1 day-1) in arthritic animals. The present study shows the antiarthritic effect of Triphala against adjuvant-induced arthritic mice.