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International Journal of Pharmacology
  Year: 2012 | Volume: 8 | Issue: 2 | Page No.: 115-121
DOI: 10.3923/ijp.2012.115.121
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The Effect of Lacidipine on Indomethacin Induced Ulcers in Rats

Bahadir Suleyman, Zekai Halici, Fehmi Odabasoglu and Fatma Gocer

In this study, the antiulcer activity of lacidipine was investigated on indomethacin-induced gastric ulcer model and it was examined whether the antiulcer effect of lacidipine was related to oxidant/antioxidant parameters in rats. Anti-ulcerative effects of lacidipine were investigated on an indomethacin-induced gastric ulcer model in rats. The antiulcer capability of lacidipine was compared to 20 mg kg-1 famotidine. Results showed that lacidipine prevented the formation of indomethacin-induced ulcers at 2 and 4 mg kg-1 doses significantly. Enzymatic and non-enzymatic antioxidant parameters, such as total glutathione, superoxide dismutase and glutathione peroxidase, were found low and enzymatic and non-enzymatic oxidant parameters, such as myeloperoxidase and malondialdehyde, were found high in the gastric tissues of indomethacin-given rats. Indomethacin acts through not only the inhibition of the synthesis of cytoprotective prostaglandins but also by affecting enzymatic and non-enzymatic, oxidant and anti-oxidant mechanisms.
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How to cite this article:

Bahadir Suleyman, Zekai Halici, Fehmi Odabasoglu and Fatma Gocer, 2012. The Effect of Lacidipine on Indomethacin Induced Ulcers in Rats. International Journal of Pharmacology, 8: 115-121.

DOI: 10.3923/ijp.2012.115.121






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