Abstract: The effect of consumption of leaves of Solanum macrocarpon L. on the Prostate Specific Antigen (PSA) level, antioxidant status and hematological parameters in albino rats induced with Benign Prostate Hyperplasia (BPH) was studied. Twenty five animals divided into five experimental groups namely Normal Control group (NC-group), Benign Prostate Hyperplasia group (BPH-group), Finasteride-group, 5% Solanum macrocarpon-supplemented diet group (5% SMSD-group) and 10% SMSD-group were used in the study. The NC was not induced with BPH and fed a control diet (diet I). The BPH-group and Finasteride-group were induced with BPH but Finasteride-group was treated with finasteride and both were fed a control diet (diet I). Five% SMSD-group and 10% SMSD-group were induced with BPH and fed with 5 and 10% S. macrocarpon-Supplemented Diet (SMSD), respectively. Benign prostate hyperplasia was induced in the animals by daily subcutaneous injections of Testosterone Propionate (TP) in olive oil for a period of 12 weeks and the animals were fed their respective diets throughout the duration. Parameters including Prostate Specific Antigen (PSA), hematological indices including hemoglobin and white blood cells in vivo antioxidant markers such as Superoxide Dismutase (SOD), Glutathione-S-Transferase (GST), glutathione (GSH) and catalase were determined. The histo-pathological changes of the prostate were also examined. The results showed that PSA levels decreased significantly (p<0.05) in groups fed with SMSD. Superoxide dismutase (SOD), Glutathione-S-Transferase (GST) and glutathione (GSH) levels increased significantly (p<0.05) while WBC were significantly decreased (p<0.05) in the groups fed SMSD. The histological studies showed a considerable improvement in the prostatic histo-architecture of the groups fed SMSD. These findings indicate that S. macrocarpon-supplemented diets may prevent or suppress the development of BPH and be useful in its treatment and management.