Abstract: The blood chemistry, hematological and oxidative stress parameters of anaemic rats fed iron-fortified Nigerian Ofada rice with Ferrazone® (NaFeEDTA) were investigated. Forty male rats were divided equally into 4 groups. Groups 1 and 2 were induced with anaemia using phenylhydrazine and were fed with and without iron fortified diet respectively, while groups 3 and 4 which served as control were non-anaemic and were fed with and without iron fortified diet respectively, for 30 days. The blood chemistry, electrolyte level, hematology, anti-oxidant enzyme activities and tissue histology were determined. Packed cell volume , hemoglobin level and red blood cell count were significantly (p<0.01) increased in rats fed with/without iron fortified diet as compared to the control. The activities of aspartate amino transferase, alanine amino transferase, direct bilirubin, creatinine and triacylglycerol levels were significantly increased in anaemic rats fed with iron fortified diet as compared with the control. There was a significant decrease in superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) level of anaemic rats fed with fortified diet as compared with the control group, while there was a significant increase in SOD and catalase activities and a decrease in MDA level of anaemic rats fed with unfortified diet. There was a significant decrease in sodium and potassium levels and increased in the brain iron levels of anaemic rats fed with iron fortified diet as compared with the control. Data of the study show that iron fortification using Ferrazone® affected the hematology, lipid peroxidation, electrolytes and blood chemistry of rats.