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Articles by Venugopal P. Menon
Total Records ( 2 ) for Venugopal P. Menon
  S. Sivabalan and Venugopal P. Menon
  The aim of the study is to know the effect of high-fat and sucrose in the development of type 2 diabetes in Wistar rats. Several factors including high caloric diets, chronic positive caloric balance and the sedentary lifestyles are proposed as the causative factors in the development of type 2 diabetes but the exact mechanism involved is not known. Numerous studies on genetic models of obesity and diabetes induced by chemical destruction of pancreas are available, but the metabolic syndrome and diabetes observed in general population is mostly different from the genetic models and chemically induced diabetes. In this study we analyzed the effect of feeding, high-fat with or without sucrose, orally for 12 weeks. The rats were divided into three groups of twelve animals each. The groups are control, high-fat and high-fat with sucrose. After 12 weeks of treatment, fasting glucose, fasting plasma insulin, glucose tolerance test, plasma triglycerides, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were analyzed. Insulin resistance was analyzed by euglycemic clamp technique. Both high-fat diet and high-fat diet with sucrose impaired the lipid profile, glucose tolerance and have caused severe insulin resistance in the normal Wistar rats.
  S. Ramachandran , N. Rajendra Prasad , K.V. Pugalendi and Venugopal P. Menon
  UV radiation-induced damages may result in pre-cancerous and cancerous lesions and acceleration of skin aging. It involves an imbalance of the endogenous antioxidant system that leads to the increase of free radical levels. Antioxidant pretreatment might inhibit such imbalance. In the present study, the photoprotective effect of ursolic acid (UA; 3β-hydroxy-urs-12-en-28-oic acid), a dietary polyphenolic phytochemical, has been examined in the UVB-(280-320 nm) irradiated human blood lymphocytes. Lymphocytes pretreated with increasing concentrations of ursolic acid (1, 5 and 10 μg mL-1) for 30 min, were irradiated and lipid peroxidation and antioxidant defense were examined. UVB-irradiated lymphocytes exhibited increased levels of lipid peroxidation and disturbances in antioxidant status. Ursolic acid pretreatment resulted in significant reduction in thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides (LPH) levels. Further, antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin-C (Vit-C) and vitamin-E (Vit-E) were normalised in ursolic acid pretreated plus UVB-treated lymphocytes. The maximum dose of ursolic acid (10 μg mL-1) normalized the UVB induced lipid peroxidation, indicating the photoprotective effect of ursolic acid in human peripheral lymphocytes under in vitro condition.
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