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Asian Journal of Biochemistry
Year: 2008  |  Volume: 3  |  Issue: 5  |  Page No.: 271 - 279

Effect of Feeding High-Fat with or Without Sucrose on the Development of Diabetes in Wistar Rats

S. Sivabalan and Venugopal P. Menon    

Abstract: The aim of the study is to know the effect of high-fat and sucrose in the development of type 2 diabetes in Wistar rats. Several factors including high caloric diets, chronic positive caloric balance and the sedentary lifestyles are proposed as the causative factors in the development of type 2 diabetes but the exact mechanism involved is not known. Numerous studies on genetic models of obesity and diabetes induced by chemical destruction of pancreas are available, but the metabolic syndrome and diabetes observed in general population is mostly different from the genetic models and chemically induced diabetes. In this study we analyzed the effect of feeding, high-fat with or without sucrose, orally for 12 weeks. The rats were divided into three groups of twelve animals each. The groups are control, high-fat and high-fat with sucrose. After 12 weeks of treatment, fasting glucose, fasting plasma insulin, glucose tolerance test, plasma triglycerides, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were analyzed. Insulin resistance was analyzed by euglycemic clamp technique. Both high-fat diet and high-fat diet with sucrose impaired the lipid profile, glucose tolerance and have caused severe insulin resistance in the normal Wistar rats.

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