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Articles by Min Chen
Total Records ( 7 ) for Min Chen
  Min Chen , Shun Huang , Yuan-Yuan Chang , Xi Zheng , Ren-Ping Zhou , Dong-Li Li and Kun Zhang
  Background and Objective: Curcumin is a bioactive natural polyphenol, but the poor bioavailability has limited its application. To be effective as a therapeutic drug, curcumin must be combined with other drugs to improve bioavailability. The aim of the present study was to investigate the effects and mechanisms of curcumin and piperine administered individually or in combination on lipopolysaccharide (LPS)-induced neuroinflammation. Materials and Methods: Mice were treated with curcumin (100 and 200 mg kg–1, p.o.) and piperine (20 mg kg–1, p.o.) for 21 days followed by LPS (250 μg kg–1, i.p.) administration for 7 days. Results: It is found that repeat injections of LPS induced neuronal damage and increased inflammatory cytokines release, while pretreatment with curcumin reversed these changes. In addition, co-administration of piperine with curcumin potentiated their neuroprotective effects as compared to the treatment with curcumin alone. It is further examined that the molecular mechanisms by which curcumin exerts its neuroprotective effects and inhibited the Toll-like receptor 4 (TLR4)-mediated downstream signaling and effectively lowered the production of inflammatory mediators. Conclusion: These findings led us to the conclusion that the effects of curcumin on LPS-induced neuroinflammation is mediated by modulating TLR4 pathway, which is enhanced by an adjuvant, piperine.
  Gaolin Wu , Guozhen Du , Min Chen and Dashuai Sun
  Six herbaceous plants native to alpine meadows of the eastern Qinghai-Tibetan Plateau were examined for their plasticity in root morphology and root biomass allocation in response to several light and nutrient levels in a field experiment. Root length, root dry weight, root length to total seedling height ratio (R/Th) and root dry weight to total seedling dry weight (R/Tw) were examined. The root morphology and biomass allocation have significant response to variation of light and nutrient availability. The seedlings root length, root weight; R/Th and R/Tw of these six species were all significantly affected by the light and nutrient. There are significant interaction effects on root length and R/Th between light and nutrient. The nutrient availability significantly increased the root length and biomass, the maximum value generally occurred in moderate nutrient availability. The shade reduced the biomass allocation to root. A higher nutrient availability improved the R/Th and R/Tw in shade conditions. But, the poor nutrient availability could increase the R/Th and R/Tw in a strong light condition. There are significant maternal effects of species on the root morphological growth and root biomass allocation. These indicated that these seedlings have different root morphology and biomass allocation strategies in different circumstance heterogeneities.
  Xinting Zheng , Kemei Peng , Juan Tang , Wei Wang , Ke Xiao , Daiyun Zhu , Shun Lu , Keli Yang , Jing Wang , Pengpeng Sun and Min Chen
  The aim of this study was to determine the effects of supplemental drinking boron on morphology of ostrich chicks’ cerebrum. Twenty four hatched ostrich chicks were divided into six group (I-VI) and supplemented by the water with 0, 40, 80, 160, 320 and 640 mg L-1 boron, respectively for 45 days. Cerebrums were obtained and weighed after dissection then measured the transverse diameter, longitudinal diameter and height of cerebral hemisphere immediately. Paraffin embedded sections of cerebral tissues (4 μm thick) were stained with HE, Nissl’s and argentaffin and then micro photographed. It showed significant increase (p<0.05 or p<0.01) in each anatomy index of group IV in comparison with the other groups while group VI showed significant decrease. Histology study showed that neurons of the cerebrum of group I and II were alike, nerve fibers passed horizontally within the cortex. Neurons of group III were varied in size and shape and with abundance of nerve fibers passed horizontally within the cortex tighter. Whereas neurons of group IV had more types than the rest of groups and were well arranged from the edge to inside by size, the nerve fibers were rich and interweaved. In contrast, neurons of group V and VI were monomorphic with less neurite and nerve fibers were tenuous and sparse. Findings showed that 80-160 mg L-1 supplemental drinking boron promotes cerebrum development, neurons differentiation, neurite formation and nerve fibers elongation of the cerebrum of 0-45 days old ostrich chicks.
  W. Matthew Sattley , Michael T. Madigan , Wesley D. Swingley , Patricia C. Cheung , Kate M. Clocksin , Amber L. Conrad , Liza C. Dejesa , Barbara M. Honchak , Deborah O. Jung , Lauren E. Karbach , Ahmet Kurdoglu , Surobhi Lahiri , Stephen D. Mastrian , Lawrence E. Page , Heather L. Taylor , Zi T. Wang , Jason Raymond , Min Chen , Robert E. Blankenship and Jeffrey W. Touchman
  Despite the fact that heliobacteria are the only phototrophic representatives of the bacterial phylum Firmicutes, genomic analyses of these organisms have yet to be reported. Here we describe the complete sequence and analysis of the genome of Heliobacterium modesticaldum, a thermophilic species belonging to this unique group of phototrophs. The genome is a single 3.1-Mb circular chromosome containing 3,138 open reading frames. As suspected from physiological studies of heliobacteria that have failed to show photoautotrophic growth, genes encoding enzymes for known autotrophic pathways in other phototrophic organisms, including ribulose bisphosphate carboxylase (Calvin cycle), citrate lyase (reverse citric acid cycle), and malyl coenzyme A lyase (3-hydroxypropionate pathway), are not present in the H. modesticaldum genome. Thus, heliobacteria appear to be the only known anaerobic anoxygenic phototrophs that are not capable of autotrophy. Although for some cellular activities, such as nitrogen fixation, there is a full complement of genes in H. modesticaldum, other processes, including carbon metabolism and endosporulation, are more genetically streamlined than they are in most other low-G+C gram-positive bacteria. Moreover, several genes encoding photosynthetic functions in phototrophic purple bacteria are not present in the heliobacteria. In contrast to the nutritional flexibility of many anoxygenic phototrophs, the complete genome sequence of H. modesticaldum reveals an organism with a notable degree of metabolic specialization and genomic reduction.
  Min Hu , Min Chen , Xiao-Gang Yang , Shao-Ming Fang and Chun-Sen Liu
  The in situ reaction of Cd(ClO4)2·6H2O with 7-oxabicyclo[2.2.1]-5-heptene-2,3-dicarboxylic anhydride in the presence of lithium hydroxide affords a 2-D CdII coordination polymer, [Cd(L)(H2O)] (1) (L = 7-oxabicyclo[2.2.1]-5-heptene-2,3-dicarboxylate), which exhibits an unusual (3,6)-connected (46·66·83)(43)2 CdI2-type topology. The luminescent and thermal properties of 1 were investigated.
  Min Chen and Dao-Feng Chen
  From the stems of Kadsura rechangiana, a new triterpenoid lactone named renchanglactone A (1), was isolated together with four known triterpenoids, kadsulactone A, mawuweizic acid, ganwuweizic acid and kadsuric acid. Their structures were determined by spectroscopic methods including 2D-NMR techniques.
  Han-Zhong Feng , Min Chen , Lee S. Weinstein and Jian-Ping Jin
  Although β-adrenergic stimuli are essential for myocardial contractility, β-blockers have a proven beneficial effect on the treatment of heart failure, but the mechanism is not fully understood. The stimulatory G protein α-subunit (Gsα) couples the β-adrenoreceptor to adenylyl cyclase and the intracellular cAMP response. In a mouse model of conditional Gsα deficiency in the cardiac muscle (Gsα-DF), we demonstrated heart failure phenotypes accompanied by increases in the level of a truncated cardiac troponin I (cTnI-ND) from restricted removal of the cTnI-specific N-terminal extension. To investigate the functional significance of the increase of cTnI-ND in Gsα-DF cardiac muscle, we generated double transgenic mice to overexpress cTnI-ND in Gsα-DF hearts. The overexpression of cTnI-ND in Gsα-DF failing hearts increased relaxation velocity and left ventricular end diastolic volume to produce higher left ventricle maximum pressure and stroke volume. Supporting the hypothesis that up-regulation of cTnI-ND is a compensatory rather than a destructive myocardial response to impaired β-adrenergic signaling, the aberrant expression of β-myosin heavy chain in adult Gsα-DF but not control mouse hearts was reversed by cTnI overexpression. These data indicate that the up-regulation of cTnI-ND may partially compensate for the cardiac inefficiency in impaired β-adrenergic signaling.
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