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Articles by J. S Choi
Total Records ( 4 ) for J. S Choi
  K. H Kim , A. H. M Kamal , K. H Shin , J. S Choi , H. Y Heo and S. H. Woo

Large-scale proteomics of three wild relatives of wheat grain (A, B, and D genomes) were analyzed by using multidimensional protein identification technology coupled to liquid chromatography quadruple mass spectrometry. A total of 1568 (peptide match ≥1) and 255 (peptide match ≥2) unique proteins were detected and classified, which represents the most wide-ranging proteomic exploitation to date. The development of standard proteomes exhibiting all of the proteins involved in normal physiology will facilitate the delineation of disease/defense, metabolism, energy metabolism, and protein synthesis. A relative proteome exploration of the expression patterns indicates that proteins are involved in abiotic and biotic stress. Functional category analysis indicates that these differentially expressed proteins are mainly involved in disease/defense (15.38%, 21.26%, and 16.78%), metabolism (8.39%, 12.07%, and 14.09%), energy metabolism (11.19%, 11.49%, and 13.42%), protein synthesis (9.09%, 9.20%, and 8.72%), cell growth and division (9.09%, 4.60%, and 6.04%), cellular organization (4.20%, 5.75%, and 5.37%), development (6.29%, 2.87%, 3.36%), folding and stability (6.29%, 8.62%, and 8.05%), signal transduction (11.19%, 7.47%, and 8.05%), storage protein (4.20%, 1.72%, and 2.01%), transcription (5.59%, 5.17%, and 4.03%), and transport facilitation (1.40%, 1.15%, and 3.36%) in A, B, and D genomes, respectively. Here, we reported genome-specific protein interaction network using Cytoscape software, which provides further insight into the molecular functions and mechanism of biochemical pathways. We provide a promising understanding about the expressed proteins and protein functions. Our approach should be applicable as a marker to assist in breeding or gene transfer for quality and stress research of cultivated wheat.

  J. S Kwon , Y. H Joo , H. J Nam , M Lim , E. Y Cho , M. H Jung , J. S Choi , B Kim , D. H Kang , S Oh , T Park and K. S. Hong

Context  Several studies have indicated that atypical antipsychotics (AAP) induce obsessive-compulsive (OC) symptoms. Research exploring the mechanism of this phenomenon, however, has been extremely limited. Considering the indirect evidence of genetic control and difficulties in developing animal models and performing gene expression studies, genetic association studies could be an important approach to understanding the molecular mechanism of AAP-induced OC symptoms. The glutamate transporter gene SLC1A1, which was recently reported to be associated with obsessive-compulsive disorder (OCD), is a promising candidate gene for susceptibility to AAP-induced OC symptoms.

Objective  To determine whether polymorphisms in SLC1A1 are associated with AAP-induced OC symptoms in patients with schizophrenia.

Design  A pharmacogenetic case-control association study.

Setting  Outpatient schizophrenia clinics.

Patients  Clinically stable patients with schizophrenia who were receiving AAP treatment (n = 94; OC group). The OC group consisted of 40 patients with AAP-induced OC symptoms, and the non-OC group consisted of 54 patients who had received AAP for more than 24 months without developing OC symptoms.

Main Outcome Measures  Allele, genotype, and haplotype frequencies. The association was tested with a logistic regression model using age, sex, and medication type as covariates.

Results  Trends of association were observed in rs2228622 and rs3780412 (nominal P = .01; adjusted permutation P = .07) for the dominant model that was the inheritance model that best fit our data. In the haplotype -based analysis, the A/C/G haplotype at rs2228622-rs3780413-rs3780412 showed a significant association with AAP-induced OC symptoms; this association withstood multiple test correction (nominal P = .01; adjusted permutation P = .04; odds ratio, 3.955; 95% confidence interval, 1.366-11.452, for dominant model).

Conclusions  These results suggest that sequence variations in SLC1A1 are associated with susceptibility to AAP-induced OC symptoms. This is the first published pharmacogenetic study on this phenomenon and provides preliminary evidence of the involvement of glutamatergic neurotransmission in the pathogenesis of AAP-induced OC symptoms.

  J. S Choi , H. S Kim , K. R Mun , D. W Kang , M. S Kang , Y. H Bang , H. S Oh , J. H Yi , Y. T Lim and G. R. Tack

Putting is a crucial stroke to determine winning in golf. Putting is more delicate than any other strokes in golf. To keep better putting stroke, psychological factors as well as physical factors are important for golfers. The purpose of this study was to compare differences in kinematic and psychological variables between winner and loser of three skilled levels during competitive golf putting tournament. The participants consisted of 3 groups based on their skill levels: PG (8 professional golfers), RG (8 recreational golfers) and NG (8 novice golfers). Each group performed 8 tournaments by attempting 2.1 m putting from the hole. 3D motion analysis system with 6 high speed cameras and BIOPAC ECG module were used to acquire kinematic data and ECG. To compare differences between winner and loser for each group, time phase of putting stroke, smoothness by jerk cost function (JC), heart rate (HR), ratio of low and high frequency component (LF/HF) in heart rate variability and CSAI-2 scores (competitive state anxiety inventory 2) were used. There was a significant difference in back-swing phase time ratio between PG and other groups and in JC at the putter toe between NG and other groups. There was a significant difference in LF/HF and self-confidence score of CSAI-2 between winner and loser within PG. While PG and RG showed similar kinematic performance, they showed different LF/HF. The tonic states derived from cardiac activity indicated that a higher skilled level was associated with increased LF. Increased LF is associated with increased automaticity and decreased attention demands, which means that increased mental workload reduces LF. For PG, it may reveal that psychological factor is one of the important factors for the better performance during competition. Further studies are necessary to clarify psychological factors of putting by using different measurement techniques such as galvanic skin response.

  J. S Choi , C. K Cain and J. E. LeDoux

Using a two-way signaled active avoidance (2-AA) learning procedure, where rats were trained in a shuttle box to avoid a footshock signaled by an auditory stimulus, we tested the contributions of the lateral (LA), basal (B), and central (CE) nuclei of the amygdala to the expression of instrumental active avoidance conditioned responses (CRs). Discrete or combined lesions of the LA and B, performed after the rats had reached an asymptotic level of avoidance performance, produced deficits in the CR, whereas CE lesions had minimal effect. Fiber-sparing excitotoxic lesions of the LA/B produced by infusions of N-methyl-d-aspartate (NMDA) also impaired avoidance performance, confirming that neurons in the LA/B are involved in mediating avoidance CRs. In a final series of experiments, bilateral electrolytic lesions of the CE were performed on a subgroup of animals that failed to acquire the avoidance CR after 3 d of training. CE lesions led to an immediate rescue of avoidance learning, suggesting that activity in CE was inhibiting the instrumental CR. Taken together, these results indicate that the LA and B are essential for the performance of a 2-AA response. The CE is not required, and may in fact constrain the instrumental avoidance response by mediating the generation of competing Pavlovian responses, such as freezing.

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