Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by Hua Tang
Total Records ( 5 ) for Hua Tang
  Hua Tang , Xin Sheng Liu , Yu Zhen Fang , Li Pan , Zhong Wang Zhang , Peng Zhou , Jian Liang Lv , Shou Tian Jiang , Wen Fa Hu , Pan Zhang , Yong Lu Wang and Yong Guang Zhang
  In recent years, as the genome sequencing technology and protein peptide chemical synthesis technology become mature, especially the proposal of epitopic biology, more and more Foot-and- mouth Disease Virus (FMDV) antigenic epitopes are revealed. Studies on epitopes have greatly promoted the development of new-type vaccines since the early 1980s. Thanks to the consecutive discovery of new epitopes, people can overcome the Major Histocompatibility Complex (MHC) restriction between species more easily. Researchers could also produce poly-vaccine containing epitopes of different serotypes. The selected epitope sequences are highly conserved in different serotypes and this is the key guarantee of cross immune response of vaccine. It is obvious that epitope will play a key role in elaborating new-type FMDV vaccines. This study summarized the epitopes of FMDV.
  Hua Tang , Xin-Sheng Liu , Yu-Zhen Fang , Li Pan , Zhong-Wang Zhang , Peng Zhou , Jian-Liang Lv , Shou-Tian Jiang , Wen-Fa Hu , Pan Zhang , Yong-Lu Wang and Yong-Guang Zhang
  The Foot-and-mouth Disease (FMD), which is the most devastating disease of livestock husbandry, drastically hinders the development of stock raising. At present the main FMD vaccine is still traditional inactivated vaccine, as its good performance in protective activity and immune efficacy, it is widely used in the world for preventing and controlling this disease, especially in developing countries. However, people have realized many disadvantages of inactivated vaccine. In order to resolve these problems, the scientists are conducting some new research about novel FMD vaccine to seek for more secure and effective vaccines. Nowadays, with the rapid development of molecular biology, researchers are paying high emphasis on novel FMD vaccines, such as, synthetic peptide vaccine, epitope-based vaccine, DNA vaccine, chimeric vaccine and so on. There is no doubt that these new-type FMD vaccines will make great contribution to the prevention and control of FMD. This study reviewed the international research progress on the traditional vaccines and novel vaccines of FMD.
  Hua Tang , Xin-Sheng Liu , Yu-Zhen Fang , Li Pan , Zhong-Wang Zhang , Peng Zhou , Jian-Liang Lv , Shou-Tian Jiang , Wen-Fa Hu , Pan Zhang , Yong-Guang Zhang and Yong-Lu Wang
  The Z-curve is a geometrical tool for visualizing and comparing genomes. Since, the curve contains the information carried by the given sequence, DNA sequences could be analyzed systematically. In this study, the ORF5 gene of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) was analyzed by the Z-curve method and the DNAstar (DNASTAR Inc.) computer programs. The results revealed by these two methods were identical. The phylogenetic tree is more digitized and the Z-curve method is more picturesque. It turned out to be that, the Z-curve method shows a widely application prospect in phylogenetic relationships analysis. However, the Z-curve method is still in its premature stage. Novel algorithms are expected to be exploited to extract more information involved in the Z-curves.
  Hua Tang , Xin-Sheng Liu , Yu-Zhen Fang , Li Pan , Zong-Wang Zhang , Peng Zhou , Jian-Liang Lv , Shou-Tian Jiang , Yong-Lu Wang and Yong-Guang Zhang
  The Z-curve is a geometrical tool for visualizing and comparing genomes. Since, the curve contains the information carried by the given sequence, DNA sequences could be analyzed systematically. In this study, the Foot and Mouth Disease Virus (FMDV) was analyzed by the Z-curve Method. This research concludes that all serotypes FMDV have a close consanguinity but each has its own characteristic by contrast, the three South African serotypes have a much closer affinity. FMDV have three A + T-rich regions and two G + C-rich regions. The most variable regions of FMDV lie in protein coding areas. And the non-coding region is very conservative. O serotype FMDV is most variable compared with A and Asia1 serotype. Those O serotype FMDV in buffalo and goat have a mutation trend. Compared with host, geographic location have a grater influence on FMDV mutation. The A serotype FMDV strains occurred in India after 2002 are more stable and have a closer phylogenetic relationships compared with the Asia1 strains which were prevalent before 2002. In general, Z-curve Method shows a widely application prospect in the areas of life sciences. Such as gene sequence, molecular epidemiology, homology, evolution, phylogenetic relationships and genetic diversity analysis.
  Xuemin Wang , Bruno D. Fonseca , Hua Tang , Rui Liu , Androulla Elia , Michael J. Clemens , Ulrich-Axel Bommer and Christopher G. Proud
  Signaling through mammalian target of rapamycin complex 1 (mTORC1) is stimulated by amino acids and insulin. Insulin inactivates TSC1/2, the GTPase-activator complex for Rheb, and Rheb·GTP activates mTORC1. It is not clear how amino acids regulate mTORC1. FKBP38 (immunophilin FK506-binding protein, 38 kDa), was recently reported to exert a negative effect on mTORC1 function that is relieved by its binding to Rheb·GTP. We confirm that Rheb binds wild type FKBP38, but inactive Rheb mutants showed contrasting abilities to bind FKBP38. We were unable to observe any regulation of FKBP38/mTOR binding by amino acids or insulin. Furthermore, FKBP38 did not inhibit mTORC1 signaling. The translationally controlled tumor protein (TCTP) in Drosophila was recently reported to act as the guanine nucleotide-exchange factor for Rheb. We have studied the role of TCTP in mammalian TORC1 signaling and its control by amino acids. Reducing TCTP levels did not reproducibly affect mTORC1 signaling in amino acid-replete/insulin-stimulated cells. Moreover, overexpressing TCTP did not rescue mTORC1 signaling in amino acid-starved cells. In addition, we were unable to see any stable interaction between TCTP and Rheb or mTORC1. Accumulation of uncharged tRNA has been previously proposed to be involved in the inhibition of mTORC1 signaling during amino acid starvation. To test this hypothesis, we used a Chinese hamster ovary cell line containing a temperature-sensitive mutation in leucyl-tRNA synthetase. Leucine deprivation markedly inhibited mTORC1 signaling in these cells, but shifting the cells to the nonpermissive temperature for the synthetase did not. These data indicate that uncharged tRNALeu does not switch off mTORC1 signaling and suggest that mTORC1 is controlled by a distinct pathway that senses the availability of amino acids. Our data also indicate that, in the mammalian cell lines tested here, neither TCTP nor FKBP38 regulates mTORC1 signaling.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility