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Asian Journal of Animal and Veterinary Advances
Year: 2012  |  Volume: 7  |  Issue: 12  |  Page No.: 1261 - 1265

The Epitopes of Foot and Mouth Disease

Hua Tang, Xin Sheng Liu, Yu Zhen Fang, Li Pan, Zhong Wang Zhang, Peng Zhou, Jian Liang Lv, Shou Tian Jiang, Wen Fa Hu, Pan Zhang, Yong Lu Wang and Yong Guang Zhang    

Abstract: In recent years, as the genome sequencing technology and protein peptide chemical synthesis technology become mature, especially the proposal of epitopic biology, more and more Foot-and- mouth Disease Virus (FMDV) antigenic epitopes are revealed. Studies on epitopes have greatly promoted the development of new-type vaccines since the early 1980s. Thanks to the consecutive discovery of new epitopes, people can overcome the Major Histocompatibility Complex (MHC) restriction between species more easily. Researchers could also produce poly-vaccine containing epitopes of different serotypes. The selected epitope sequences are highly conserved in different serotypes and this is the key guarantee of cross immune response of vaccine. It is obvious that epitope will play a key role in elaborating new-type FMDV vaccines. This study summarized the epitopes of FMDV.

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