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Articles by Dina Soliman Khater
Total Records ( 2 ) for Dina Soliman Khater
  Dina Soliman Khater , Rehab Fawzi Kasem and Reham Awad Morsy
  Background and Objective: Odontogenic tumors comprise a complex group of lesions which can pretense diagnostic challenges because of overlapping and diverse histopathologic types and clinical behaviors. An understanding of the biological behavior of these lesions is of fundamental importance for the final diagnosis and treatment planning, as these have an influence on the prognosis. The goal of the present study was to analyze and correlate the immunohistochemical expression of NF-κB and its transcription targets Bcl-xL and COX-2 in different odontogenic tumors. Materials and Methods: Thirty paraffin blocks of different odontogenic tumors (six dentigerous cyst, fourteen simple ameloblastoma, five unicystic ameloblastoma and five ameloblastic carcinoma) were selected. Immunohistochemistry was performed using the standard method (Avidin biotin peroxidase) to detect the polyclonal anti-NF-κB, Bcl-xL and COX-2 antibodies. One-way ANOVA and Spearman correlation test was used for statistical analyses. Results: The overall expression of the three antibodies (NF-κB, Bcl-xL and COX-2) increased significantly (p-value was considered significant when p<0.05) from dentigerous cyst to ameloblastoma and reached their highest values in the cases of ameloblastic carcinoma. Conclusion: The interaction between the three proteins in blocking apoptosis and increasing proliferation may constitute an important pathogenic mechanism of tumorigenesis and hence might play a role in the behavior of odontogenic tumors.
  Safa Fathy Abd El-Ghani , Rehab Fawzi Kasem , Dina Soliman Khater and Olfat G. Shaker
  Background and Objective: Lymphomas are malignant neoplastic proliferations that cause major health problems worldwide. However, the precise pathogenesis and underlying molecular mechanisms of both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) are not fully elucidated. Accordingly, the aim of the present study was to detect the expression of MSH2 at the gene and protein levels in HL and NHL of the head and neck. Materials and Methods: Expression of MSH2 on gene and protein levels were detected using quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry respectively. A total of 26 archival specimens were selected including normal lymph nodes (6 cases) which were used as a control group, lingual tonsils with lymphoid hyperplasia (6 cases) and 14 cases of lymphomas of submandibular and sublingual lymph nodes. Lymphomas were classified into of HL (6 cases of mixed cellularity type) and NHL (8 cases of diffuse B cell lymphoma). Results: Lower expression of MSH2 in NHL than HL was also observed. Moreover, a positive correlation was detected between the expression of MSH2 protein and its mRNA among the examined groups. Conclusion: Lower expression of MSH2 in NHL than that of HL suggested a more aggressive behavior and poor prognosis in this lesion. The reduced expression of MSH2 could be considered as a molecular biomarker for loss of MMR activities and it might serve as a prognostic biomarker for head and neck lymphomas.
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