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Articles by A. Fatih Fidan
Total Records ( 4 ) for A. Fatih Fidan
  A. Fatih Fidan , Ismail Kucukkurt , Hayati Yuksel , Ayse Ozdemir , Sinan Ince and Yilmaz Dundar
  The aim of this study, was to examine the effects of Yucca schidigera, Quillaja saponaria and mixture of both plants on tissue antioxidant defense systems, lipid peroxidation and histopathological changes on streptozotocin-induced diabetic rats. Animals were allocated into 5 groups of each containing 10 rats. Control (C) and Diabetic Control group (D) were fed by Standart Rat Feed (SRF). The other diabetic groups, Yucca schidigera group (DY), Quillaja saponaria group (DQ) and mix group (DQY) were fed ad libitum using SRF +100 ppm Yucca schidigera powder (Sarsaponin 30®), SRF +100 ppm Quillaja saponaria powder (Nutrafito®) and SRF+100 ppm Yucca schidigera-Quillaja saponaria powder (Nutrafito Plus®), respectively for 3 weeks. MDA levels in liver and kidney of the rats significantly increased in D group compared to control. MDA levels in DY, DQ and DQY groups significantly decreased in liver and kidney of the diabetic rats. On the other hand, the liver and kidney GSH concentrations significantly decreased in D, DY and DQY groups compared to control and DQ group. The SOD levels in liver significantly increased in DY, DQ and DQY groups compared to D group. The kidney SOD levels in D and DY group significantly decreased compared to control and other groups. On the other hand, treatment of diabetic rats with Quillaja saponaria and Quillaja saponaria-Yucca schidigera mixtures prevented the alteration in liver and kidney pathology with the return to their normal texture. Consequently, in buffering the negative impacts of increased oxidative stress in DM and in preventing or mitigating diabetic complications, it was seen that Quillaja saponaria was more effective than Yucca schidigera. Moreover, it can be considered that these plants could support the treatment of the disease by antioxidant effects.
  Ismail Kucukkurt , Sinan Ince , A. Fatih Fidan and Ayse Ozdemir
  The study was aimed to determine the possible protective role of diet suplementation of Yucca schidigera (Ys) powder against basal oxidative damage in blood and some tissue on rats. The rats were divided into 3 groups: Control, Ys1 and Ys2. Control group was fed by Standart Rat Feed (SRF). The other groups, Ys1 and Ys2 were fed ad libitum by SRF +100 ppm Ys powder (Sarsaponin 30®), SRF + 200 ppm Ys powder (Sarsaponin 30®), respectively for 4 weeks during the study. MDA levels in blood and kidney of the rats significantly decreased in Ys1 and Ys2 groups compared to control. Whereas, liver MDA levels of Ys1 and Ys2 groups didnít show any significant change. The kidney GSH concentrations were significantly increased in the Ys2 group compared to control. Blood and liver GSH concentrations between groups did not differ. Consequently, 100 and 200 ppm supplementation of Ys powder to the diets of rats decrease the blood and kidney MDA levels and increase the kidney GSH concentrations. It is thought that Ys can be used effectively as an antioxidant suplement. Moreover, the usage of the plant, did not affect the liver MDA and GSH as well as blood GSH levels.
  A. Fatih Fidan , I. Hakk Cigerci , Nalan Baysu-Sozbilir , Ismail Kucukkurt , Hayati Yuksel and Hikmet Keles
  In the present study, we have sought the effects of lindane on antioxidant parameters and nitric oxide (NOx) levels of blood, liver, kidney and brain, as well as its histopathological evaluation in rats. The rats were divided into four groups each containing 10 rats: control; L10, L20 and L40. C group was administered by 1 mL day 1 pure olive oil. The other groups, L10, L20 and L40 were administrered by 10, 20 and 40 mg/kg/bw orally lindane, respectively for 4 weeks. Administration of lindane caused an increase in malondialdehyde (MDA), total antioxidan activities (AOA) and NOx concentrations in blood (p<0.05), but 10 mg kg-1 dosage of lindane treatment did not cause any difference in blood and tissue MDA levels. Moreover, MDA levels in the liver, kidney and brain increased (p<0.05) at 20 and 40 mg kg-1 dosage of lindane treatment. The liver, kidney and brain reduced glutathione (GSH) concentrations decreased in all lindane groups (p<0.05). An increase in the kidney NOx concentrations was observed in lindane treated animals (p<0.05). However, liver NOx levels were increased only L40 group (p<0.05). Brain GSH concentrations between groups did not differ. Histopathologically, severe liver and kidney congestion were detected in lindan groups, but no specific changes was seen in the brain. While no significant histopathological changes were observed in the tissues of the animals in L10 group, megalocytosis in hepatocytes, periacinar settled parancimateus and vacuolar degeneration as well as sinusoidal and venous c ongetion and also periportal lymphocytic infiltrations were observed in liver of L20 and L40 groups. Medullar and cortical haemorrhagie, degeneration and vacuolisations of proximal convoluted tubules were seen in kidney. Furthermore, hyperemie was seen in the parancimateus brain vessels.
  A. Fatih Fidan , Huseyin Enginar , I. Hakki Cigerci , S. Elif Korcan and Ayse Ozdemir
  The present study, was designed to determine the possible protective effects of Spinacia oleracea L. extract (S.E) and Aesculuc hippocastanum L. extract (AE) against oxidative tissue damage induced by radiation as well as examinig their in vitro antibacterial potential. The animals were divided totally 4 groups as Control (C), Radiation (R), S.E Extract + Radiation (SER) and AE Extract + Radiation (AER) group. AER and SER groups were also separated to 2 subgroups as SER 1, SER 15, AER 1 and AER 15. C group was administered by 1 mL 0,9 % saline every other day during 20 days. The R group rats were received 1 mL q 0,9% saline every other day i.p. and other day 0.5 Gy radiation during 20 days (n = 10). The other groups, SER and AER were administered by 50 mg kg 1 i.p. S.E and AE extract every other day and other day 0.5 Gy radiations, respectively for 20 days. At the end of experimental period, the animals sacrificed by anesthetizing at 1 (group-C, R, SER 1 and AER 1) and 15 days (group-SER 15 and AER 15) postirradiation. Malondialdehyde (MDA) and reduced Glutathione (GSH) levels in tissues and in vitro antimicrobial activity in the plant extracts were determined. The results indicate that S.E and AE treatment decreases the tissue oxidative stress in irradiation-induced oxidative tissue damage by maintaining the GSH recycling activity and free radical scavenging potential. Moreover, our results demonstrate that, in animals exposed to irradiation,S.E and AE could provide great advantages against to systemic infection from endogenous and exogenous organisms increased after exposure to ionizing radiation. Consequently, the natural compound found in S. oleracea and A. hippocastanum including antioxidants, antimicrobials and other phytonutrients, substantially could be protect the tissue from radiation damage and its complications.
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