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Journal of Animal and Veterinary Advances
Year: 2008  |  Volume: 7  |  Issue: 11  |  Page No.: 1480 - 1488

The Effects of the Dose-dependent -hexachlorocyclohexane (Lindane) on Blood and Tissue Antioxidant Defense Systems, Lipid Peroxidation and Histopathological Changes in Rats

A. Fatih Fidan, I. Hakk Cigerci, Nalan Baysu-Sozbilir, Ismail Kucukkurt, Hayati Yuksel and Hikmet Keles    

Abstract: In the present study, we have sought the effects of lindane on antioxidant parameters and nitric oxide (NOx) levels of blood, liver, kidney and brain, as well as its histopathological evaluation in rats. The rats were divided into four groups each containing 10 rats: control; L10, L20 and L40. C group was administered by 1 mL day 1 pure olive oil. The other groups, L10, L20 and L40 were administrered by 10, 20 and 40 mg/kg/bw orally lindane, respectively for 4 weeks. Administration of lindane caused an increase in malondialdehyde (MDA), total antioxidan activities (AOA) and NOx concentrations in blood (p<0.05), but 10 mg kg-1 dosage of lindane treatment did not cause any difference in blood and tissue MDA levels. Moreover, MDA levels in the liver, kidney and brain increased (p<0.05) at 20 and 40 mg kg-1 dosage of lindane treatment. The liver, kidney and brain reduced glutathione (GSH) concentrations decreased in all lindane groups (p<0.05). An increase in the kidney NOx concentrations was observed in lindane treated animals (p<0.05). However, liver NOx levels were increased only L40 group (p<0.05). Brain GSH concentrations between groups did not differ. Histopathologically, severe liver and kidney congestion were detected in lindan groups, but no specific changes was seen in the brain. While no significant histopathological changes were observed in the tissues of the animals in L10 group, megalocytosis in hepatocytes, periacinar settled parancimateus and vacuolar degeneration as well as sinusoidal and venous c ongetion and also periportal lymphocytic infiltrations were observed in liver of L20 and L40 groups. Medullar and cortical haemorrhagie, degeneration and vacuolisations of proximal convoluted tubules were seen in kidney. Furthermore, hyperemie was seen in the parancimateus brain vessels.

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