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Articles by Yusuf OZTURK
Total Records ( 2 ) for Yusuf OZTURK
  Elif Kaya-Tilki , Miris Dikmen and Yusuf Ozturk
  Neuropathological characteristics of neurodegenerative disorders are atrophy or loss of specific neurons in the specific brain areas. Small-molecule products like epigenetic drugs, which can activate silenced genes, regulate chromatin remodelling and transcription, is presently been focused as an alternative approach for eliciting neuritogenic activity. Trichostatin A (TSA) has been effectively investigated for cancer treatment but it also has been shown to possess neuritogenic potential. In this study, it was aimed to compare the neuritogenic effects of two epigenetic drugs on PC-12 Adh cell line, which are the histone deacetylase inhibitor (HDACi) trichostatin A and a novel non-covalent DNA methyltransferase inhibitor (DNMTi) RG108. Cytotoxic effects were determined by MTT assay. Cell differentiation and migration analysis were evaluated by xCELLigence Real Time Cell Analyzer Dual Plate (RTCA DP) system according to the changing in Cell Index (CI) values. Cell migration analysis was also corroborated with morphological migration analysis. Matrix metalloproteinase-2 (MMP-2) levels related with neurite outgrowth were measured by ELISA. Finally, neurite outgrowth was observed with immunofluorescence staining and determined by neurite outgrowth analysis on PC-12 Adh cell line. The RG108 was found nearly as effective as TSA on neuronal differentiation, neurite outgrowth and cellular migration in PC-12 Adh cell line in a combination with nerve growth factor. According to the results, DNA methyltransferase inhibitors also hold promise in neurodegenerative disorders.
  Nurcan BEKTAS and Yusuf OZTURK
  Aim: To identify the effects of antioxidants on gastrointestinal smooth muscle complications in 6-week streptozotocine (STZ)-induced diabetic rats. Materials and methods: The following steps were carried out: 1. Three weeks after STZ injection, saline and 10 mg/kg p-OH benzoic, protocatechic, and gallic acids were separately administered to the rat groups every day for 3 weeks. 2. The responses of the fundus and ileum to agonists were recorded using isolated organ bath experiments. Results: Diabetic smooth muscle complications developed in the diabetic rats. The responses of the ileum to acetylcholine increased whereas the responses of the fundus to serotonine decreased in the diabetic rats. The test drugs inhibited and promoted but did not affect the smooth muscle complications in the diabetic rats, and sometimes they affected the smooth muscle activity, which did not change with diabetes. Conclusion: The antioxidants used elicited pro-oxidant activation and/or exhibited effects independent of diabetic complications of gastrointestinal smooth muscles in the experimental conditions applied.
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