Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Turkish Journal of Medical Sciences
Year: 2012  |  Volume: 42  |  Issue: 2  |  Page No.: 211 - 216

Effects of phenolic acids on gastrointestinal smooth muscle complications in streptozotocine-induced diabetic rats

Nurcan BEKTAS and Yusuf OZTURK    

Abstract: Aim: To identify the effects of antioxidants on gastrointestinal smooth muscle complications in 6-week streptozotocine (STZ)-induced diabetic rats. Materials and methods: The following steps were carried out: 1. Three weeks after STZ injection, saline and 10 mg/kg p-OH benzoic, protocatechic, and gallic acids were separately administered to the rat groups every day for 3 weeks. 2. The responses of the fundus and ileum to agonists were recorded using isolated organ bath experiments. Results: Diabetic smooth muscle complications developed in the diabetic rats. The responses of the ileum to acetylcholine increased whereas the responses of the fundus to serotonine decreased in the diabetic rats. The test drugs inhibited and promoted but did not affect the smooth muscle complications in the diabetic rats, and sometimes they affected the smooth muscle activity, which did not change with diabetes. Conclusion: The antioxidants used elicited pro-oxidant activation and/or exhibited effects independent of diabetic complications of gastrointestinal smooth muscles in the experimental conditions applied.

View Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

No Article Found
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility