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Articles by Yonghong Zhou
Total Records ( 2 ) for Yonghong Zhou
  Louise M. Randall , Fiona H. Amante , Karli A. McSweeney , Yonghong Zhou , Amanda C. Stanley , Ashraful Haque , Malcolm K. Jones , Geoff R. Hill , Glen M. Boyle and Christian R. Engwerda
  Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection, predominantly experienced by children and nonimmune adults, which results in significant mortality and long-term sequelae. Previous studies have reported distinct susceptibility gene loci in CBA/CaH (CBA) and C57BL/6 (B6) mice with experimental CM (ECM) caused by infection with Plasmodium berghei ANKA. Here we present an analysis of genome-wide expression profiles in brain tissue taken from B6 and CBA mice with ECM and report significant heterogeneity between the two mouse strains. Upon comparison of the leukocyte composition of ECM brain tissue, microglia were expanded in B6 mice but not CBA mice. Furthermore, circulating levels of gamma interferon, interleukin-10, and interleukin-6 were significantly higher in the serum of B6 mice than in that of CBA mice with ECM. Two therapeutic strategies were applied to B6 and CBA mice, i.e., (i) depletion of regulatory T (Treg) cells prior to infection and (ii) depletion of CD8+ T cells after the establishment of ECM. Despite the described differences between susceptible mouse strains, depletion of Treg cells before infection attenuated ECM in both B6 and CBA mice. In addition, the depletion of CD8+ T cells when ECM symptoms are apparent leads to abrogation of ECM in B6 mice and a lack of progression of ECM in CBA mice. These results may have important implications for the development of effective treatments for human CM.
  Haiqing Yu , Chunbang Ding , Chun Zhang and Yonghong Zhou
  In order to obtain more cytological data, the karyotypes of Pseudoroegneria gracillima and P. kosaninii were investigated. Root tips of P. gracillima and P. kosaninii were pretreated in an ice bath, fixed in a mixture of 95% ethanol: glacial acetic acid and treated in 1 M HCl at 60°C in a water bath. Somatic cells were stained in Schiff at room temperature and the meristematic portions of the root tips were squashed in 45% acetic acid. The results show that: (1) P. gracillima is diploid with two pairs of satellites and P. kosaninii is octoploid with three pairs of satellites. The karyotypes of diploid P. gracillima and octoploid P. kosaninii are first reported, (2) the karyotype formulas of P. gracillima and P. kosaninii are 2n = 2x = 14 = 12 m (2sat)+2sm (2sat) and 2n = 8x = 56 = 42 m (6sat)+12sm+2st, respectively and (3) the karyotype of P. gracillima is 1A type, while P. kosaninii is 2B type. This demonstrated that there are great variations between the karyotypes of P. gracillima and P. kosaninii.
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