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Articles by Yan Liu
Total Records ( 10 ) for Yan Liu
  Zhou-jun Wang , Yuan Liu , Peng Shi , Chang-jun Liu and Yan Liu
  This work aimed at elucidating the beneficial effect of plasma treatment on the catalytic performance of palladium (Pd) catalysts in methane combustion with the ordered mesoporous molecular sieve Al-MCM-41 as the model support. The plasma treated Pd/Al-MCM-41 catalyst exhibited a higher initial activity and a better stability in comparison with the untreated counterpart catalyst. To clarify the plasma effect, the catalysts were characterized by N2 sorption analysis, X-ray diffraction (XRD), temperature-programmed desorption of ammonia (NH3-TPD), pyridine adsorption-infrared spectroscopy (Py-IR), high resolution-transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS) and temperature-programmed reduction (CH4-TPR) experiments. The results obtained confirmed that palladium oxide (PdO) was the active phase. Plasma treatment enhanced the acidity of catalyst and improved the dispersion of PdO particles, which lead to a higher initial activity. The better stability for plasma treated Pd-based catalyst was proved to be closely related to the stronger interaction between palladium oxide and the molecular sieve support. In addition, the sintering of PdO particles over the plasma treated catalyst was not significant during the stability test. These findings may provide useful guidelines for further catalyst design for methane combustion.
  Peng Yu , Wei Zhou , Yu Zhao , Hui Sun , Jian Liu and Yan Liu
  Keeping the wind power constant is essential for the large-scale integration of wind power into electric power system. In this study, we classify the wind power fluctuation and propose a method of suppressing the fluctuant wind power by an Active-Parallel Hybrid Energy Storage System (APHESS). The APHESS consists of a battery, a supercapacitor and two charge-discharge controllers. By designing the configuration logically, the APHESS obtains the enhanced energy storage performance and the low investment cost. In order to realize the wind power suppression, the method of controlling the APHESS to exchange power precisely with the wind power system is developed in this study. For the purpose of making the battery and supercapacitor balance, respectively different kinds of fluctuation classified in this study, the power within APHESS is allocated reasonably between the battery and the supercapacitor. By the method proposed in this study, the fluctuant wind power can be balanced effectively and the service life of energy storage system can be prolonged.
  Libin Xu , Yan Liu , Xia Zhu , Yong Shi and Dongsheng Li
  In the present study, a multi-layer perception neural network and Radial Basis Function (RBF) network were used to model of extract form lotus seed liquor lees of furfural content. Artificial neural network were used to model extract furfural from lotus seed liquor lees and comparison with the results obtained from a regression analysis. Owing to the furfural in lotus seed liquor was easy to mix with organic matter in any proportion. The appropriate extraction conditions guaranteed the maximum extract from lotus seed liquor lees. This study provided a theoretical basis for the production of liquor.
  Yan Liu and Dongkun Luo
  China has abundant CBM resource, due to technical restraints, not all CBM resources are suitable for development. In that case, one crucial problem faced by the decision makers is how to select the CBM areas which suit best for further exploration and development. In different kinds of optimal selection methods, geological factors play an important role. Generally, geological factors are scored by expert estimation, in order to determine each of their weights in the optimal selection. However, the treatment of weight determination for those factors is rather subjective, lacking objective basis. For that matter, this study analyzes the correlation between NPV and four geological factors, aiming at finding their influences on economic results of CBM development. The study will provide an objective basis for determining the weight for each geological factor in CBM enriched areas optimal selection.
  Yan Liu and Xiaowei Sun
  Background and Objective: Diabetes augments the vulnerability of patients to get affected with several other diseases. In the present study, a prospective cross sectional investigation at a tertiary care hospital in Jingzhou, China during February, 2016-October, 2016, evaluating aetiology of diabetes mellitus and its implications was conducted. Materials and Methods: The patients were classified into three classes: (1) Patients with a prior medical history of diabetes, (2) Patients with no specific reasons for diabetes and (3) Patients without diabetes. In this study, a total of 495 patients (321 females and 174 males) were admitted during present study tenure. Among these patients 256 fell into Class I, 65 patients come into Class II and 174 into Class 3. In around 64.8% patients diabetes was main cause for the hospital admissions. Patients suffering from diabetes mellitus or new occurrence of hyperglycemia were substantially elder than patients without diabetic mellitus. Results: The most general causes for hospitalizations in the study were bronchial asthma 51 (10.3%), cerebrovascular disease 75 (15.1%), hyperlipidemia 148 (29.8%) and coronary heart disease 221 (46%). Conclusion: In the current study, it was observed that the common most etiologies for hospitalization were bronchial asthma, cerebrovascular disease, hyperlipidemia and coronary heart disease. In lieu of the findings of the current study suggests that regular check-up must be conducted for diabetic people as it could augment the probability, which may prevent imminent diabetes derived complications, specifically in elderly patients.
  Huabin Zhu , Bo Lin , Jun Chen , Haisheng Hao , Xueming Zhao , Shujing Li , Weihua Du , Tong Qin , Yan Liu and Dong Wang
  A rapid and simple PCR sex identification of embryo is very important for bovine embryo transferring. Many sex identification methods using duplex PCR were established according to Sry gene. But the identification process was affected greatly by more primers interaction. In order to decrease the interference from more primers, researchers explored a simple and rapid PCR Method. The sequences of Amelogenin alleles located at both sex chromosomes were downloaded from GenBank. A pair of sex specific primers was designed to span the 63 bp longer insertion sequence in X chromosome. Bovine samples of blood, fibroblasts and demi-embryos were sexed with these primers. Two-temperature PCR cycling program was used in which the extension step was deleted while the denaturizing and annealing steps were shortened to 1 sec. The results shown ideal identification were obtained and observable amplification were also obtained using even single fibroblast. About 20 bovine embryos were identified by this PCR cycling program and 15 embryos (9 females and 6 males) were transferred. The sexing results were confirmed by the anatomically proven sex after parturition, respectively. The comparison of amplification results between blood samples of bovine and human shows the excellent, specificity to bovine. Thus, a simple, rapid and effective PCR sex identification method was established.
  Yan Liu , Teng Ma , Weihua Du , Haisheng Hao , Dong Wang , Xueming Zhao , Haijing Li , Qiuling Jiang and Huabin Zhu
  Intramuscular Fat (IMF) is an important factor affecting meat quality. The objective of this study was to investigate the expression changes of genes related to IMF formation in muscles of Small Tail Han sheep. These genes include Acetyl CoA Carboxylase (ACC), Fatty Acid Synthase (FAS), Diacylglycerol Acyltransferase 1 (DGAT1), Heart Fatty Acid Binding Protein (H-FABP), CCAAT-Enhancer-Binding Protein α (C/EBPα), Peroxisome Proliferator-Activated Receptor γ (PPARγ), Malic Enzyme ( ME) and Lipoprotein Lipase (LPL). In the longissimus dorsi, IMF content continuously increased with growth and was significantly different (p<0.05) at all 4 months; however, IMF content reached a maximum at 5 months in the gluteus maximus. The gene expression patterns of the 8 genes involved in IMF synthesis mainly followed one of 2 trends: gene expression tended to be lowest at 4 or 5 months and then subsequently increase in the longissimus dorsi whereas gene expression tended to peak at 4 or 5 months and then subsequently decrease in the gluteus maximus. Intramuscular fat content correlated with the expression levels of all genes in the longissimus dorsi and all genes except DGAT1, H-FABP in the gluteus maximus. Remarkably, all of the above correlations between IMF and gene expression levels were positive. In conclusion, the correlation between gene expression levels and IMF content indicate that these genes play an important role in the deposition of IMF in Small Tail Han sheep.
  Runhua Liu , Lizhong Wang , Chong Chen , Yan Liu , Penghui Zhou , Yin Wang , Xirui Wang , Julie Turnbull , Berge A. Minassian , Yang Liu and Pan Zheng
  Glycogen synthase kinase 3β (GSK-3β) represses cell cycle progression by directly phosphorylating cyclin D1 and indirectly regulating cyclin D1 transcription by inhibiting Wnt signaling. Recently, we reported that the Epm2a-encoded laforin is a GSK-3β phosphatase and a tumor suppressor. The cellular mechanism for its tumor suppression remains unknown. Using ex vivo thymocytes and primary embryonic fibroblasts from Epm2a/ mice, we show here a general function of laforin in the cell cycle regulation and repression of cyclin D1 expression. Moreover, targeted mutation of Epm2a increased the phosphorylation of Ser9 on GSK-3β while having no effect on the phosphorylation of Ser21 on GSK-3α. In the GSK-3β+/+ but not the GSK-3β–/– cells, Epm2a small interfering RNA significantly enhanced cell growth. Consistent with an increased level of cyclin D1, the phosphorylation of retinoblastoma protein (Rb) and the levels of Rb-E2F-regulated genes cyclin A, cyclin E, MCM3, and PCNA are also elevated. Inhibitors of GSK-3β selectively increased the cell growth of Epm2a+/+ but not of Epm2a/ cells. Taken together, our data demonstrate that laforin is a selective phosphatase for GSK-3β and regulates cell cycle progression by GSK-3β-dependent mechanisms. These data provide a cellular basis for the tumor suppression activity of laforin.
  Ming Chen , Xin-Ru Li , Yan-Xia Zhou , Ke-Wei Yang , Xing-Wei Chen , Qiu Deng , Yan Liu and Li-Jun Ren
 

The objective of this work was to explore the potential of ultraflexible liposomes as carriers for improving the absorption of salmon calcitonin (sCT) through intranasal administration. The average diameters of positively charged ultraflexible liposomes ranged from about 73 to 99 nm, while those of negatively charged ones were 114 and 157.6 nm, respectively. The content of sodium deoxycholate in liposomes markedly affected the size and encapsulated efficiency of liposomes. The absorption of sCT through intranasal administration was evaluated by hypocalcemic efficacy in rats. The total Ca decrease D% of sCT-loaded ultraflexible liposomes with positive and negative charges were significantly bigger than that of sCT solution, while there was no significant difference in the hypocalcemic efficacy between plain liposome and sCT solution. Unexpectedly, the hypocalcemic efficacy of sCT-loaded ultraflexible liposomes with positive charges was not significantly better than those with negative charges. The decrease rate and extent of the serum calcium level for subcutaneous injection of sCT solution were almost equivalent to those for intranasal administration of negatively and positively charged ultraflexible liposomes within the first 2 h, indicating that the ultraflexible liposomes could quickly enhance the penetration of the drug during their residence in the nasal cavity. The results of the toxicity of sCT-loaded ultraflexible liposomes to nasal mucosa demonstrated that the ultraflexible liposomes exerted slight toxicity on the nasal mucosa. On an overall evaluation, the ultraflexible liposomes may be a useful vehicle for intranasal delivery of sCT.

  Francisca C. Gushiken , Vimal Patel , Yan Liu , Subhashree Pradhan , Angela L. Bergeron , Yuandong Peng and K. Vinod Vijayan
  Integrin αIIbβ3 activation is critical for platelet physiology and is controlled by signal transduction through kinases and phosphatases. Compared with kinases, a role for phosphatases in platelet integrin αIIbβ3 signaling is less understood. We report that the catalytic subunit of protein phosphatase 2A (PP2Ac) associates constitutively with the integrin αIIbβ3 in resting platelets and in human embryonal kidney 293 cells expressing αIIbβ3. The membrane proximal KVGFFKR sequence within the cytoplasmic domain of integrin αIIb is sufficient to support a direct interaction with PP2Ac. Fibrinogen binding to αIIbβ3 during platelet adhesion decreased integrin-associated PP2A activity and increased the phosphorylation of a PP2A substrate, vasodilator associated phosphoprotein. Overexpression of PP2Acα in 293 cells decreased αIIbβ3-mediated adhesion to immobilized fibrinogen. Conversely, small interference RNA mediated knockdown of endogenous PP2Acα expression in 293 cells, enhanced extracellular signal-regulated kinase (ERK1/2) and p38 activation, and accelerated αIIbβ3 adhesion to fibrinogen and von Willebrand factor. Inhibition of ERK1/2, but not p38 activation, abolished the increased adhesiveness of PP2Ac α-depleted 293 cells to fibrinogen. Furthermore, knockdown of PP2A expression in bone marrow-derived murine megakaryocytes increased soluble fibrinogen binding induced by protease-activated receptor 4-activating peptide. These studies demonstrate that PP2Ac α can negatively regulate integrin αIIbβ3 signaling by suppressing the ERK1/2 signaling pathway.
 
 
 
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