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Articles by Y. Iwatani
Total Records ( 2 ) for Y. Iwatani
  S Kuroda , M Watanabe , T Santo , Y Shimizuishi , T Takano , Y Hidaka , T Kimura and Y. Iwatani
  Background

There are few data on oxidative stresses during and after pregnancy, although aggravation of autoimmune disease is implicated in oxidative stress and occurs frequently in the postpartum period. Thioredoxin (TRX) is a stress-inducible protein, and is used as a good biomarker for oxidative stress. To clarify the changes in the levels of oxidative stress during and after pregnancy, we examined serum TRX levels and the numbers of lymphocyte subsets.

Methods

We measured serum TRX levels by enzyme-linked immunosorbent assay (ELISA), and neutrophils, lymphocytes, and CD4 and CD8 lymphocytes by flow cytometry in peripheral blood from 88 healthy pregnant women, 26 just after delivery women, 77 healthy postpartum women and 19 healthy non-pregnant women.

Results

The serum levels of TRX did not change during pregnancy, but increased in four, seven and 10 months postpartum. Serum TRX levels were correlated with the percentages of neutrophils in normal non-pregnant women and women one month postpartum, and with those of CD8 lymphocytes in early pregnant women and women one and four months postpartum.

Conclusions

Oxidative stress increased in the postpartum period, and the levels at one and four months postpartum were related to CD8 lymphocytes.

  K Kuromoto , M Watanabe , K Adachi , K Ohashi and Y. Iwatani
  Background

It is important to predict the development of pre-eclampsia (PE) during early pregnancy to prevent its occurrence later on. In this study, we studied urinary biochemical parameters and blood pressure (BP) during and after pregnancy to find useful parameters for predicting PE.

Methods

A case-control study was performed in 25 PE patients and 172 normotensive pregnant women. Twelve biochemical parameters were measured in spot urine, and the systolic and diastolic BPs were measured using an automated device during pregnancy and six to eight weeks after birth.

Results

A multiple logistic regression analysis showed that the combinations of urinary creatinine (Cr) and systolic BP (SBP) in the first trimester of pregnancy (8.9 ± 2.6 weeks), and of urinary inorganic phosphorus (IP)/Cr and SBP in the second trimester of pregnancy (19.0 ± 1.6 weeks) were useful for predicting PE. The area under the curve in the receiver operator characteristic curve of the combination of urinary Cr and SBP in the first trimester was 0.85 (95% confidence interval [CI] 0.74–0.96), and that of the combination of urinary IP/Cr and SBP in the second trimester was 0.91 (95% CI: 0.86–0.97). When used 249 mg/dL in urinary Cr and 128 mmHg in SBP as their cut-off points, the combination in the first trimester increased the accuracy (sensitivity 75% and specificity 95%) in predicting PE, as compared with that of urinary Cr (29%, 99%) or SBP (50%, 98%).

Conclusions

Combination of urinary Cr and SBP in early pregnancy and that of urinary IP/Cr and SBP in mid-pregnancy are useful for the prediction of PE.

 
 
 
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