Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Annals of Clinical Biochemistry
Year: 2010  |  Volume: 47  |  Issue: 1  |  Page No.: 62 - 66

Postpartum increase of serum thioredoxin concentrations and the relation to CD8 lymphocytes

S Kuroda, M Watanabe, T Santo, Y Shimizuishi, T Takano, Y Hidaka, T Kimura and Y. Iwatani    

Abstract: Background

There are few data on oxidative stresses during and after pregnancy, although aggravation of autoimmune disease is implicated in oxidative stress and occurs frequently in the postpartum period. Thioredoxin (TRX) is a stress-inducible protein, and is used as a good biomarker for oxidative stress. To clarify the changes in the levels of oxidative stress during and after pregnancy, we examined serum TRX levels and the numbers of lymphocyte subsets.

Methods

We measured serum TRX levels by enzyme-linked immunosorbent assay (ELISA), and neutrophils, lymphocytes, and CD4 and CD8 lymphocytes by flow cytometry in peripheral blood from 88 healthy pregnant women, 26 just after delivery women, 77 healthy postpartum women and 19 healthy non-pregnant women.

Results

The serum levels of TRX did not change during pregnancy, but increased in four, seven and 10 months postpartum. Serum TRX levels were correlated with the percentages of neutrophils in normal non-pregnant women and women one month postpartum, and with those of CD8 lymphocytes in early pregnant women and women one and four months postpartum.

Conclusions

Oxidative stress increased in the postpartum period, and the levels at one and four months postpartum were related to CD8 lymphocytes.

View Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

No Article Found
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility