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Articles by X Dong
Total Records ( 5 ) for X Dong
  H Tang , X Dong , R. S Day , M. M Hassan and D. Li
 

To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with pancreatic adenocarcinoma and 648 healthy controls in a case–control study. Information on risk factors was collected by personal interview and dietary information was collected by a self-administered food frequency questionnaire. Genotypes were determined using the Taqman method. Adjusted odds ratio (AOR) and 95% confidence interval (CI) were estimated by unconditional logistic regression. No significant main effect of genotype was observed. A borderline significant interaction between diabetes and SOD2 Ex2+24T>C CT/TT genotype was observed (Pinteraction = 0.051); the AORs (95% CI) were 0.98 (0.73–1.32) for non-diabetics carrying the CT/TT genotype, 1.73 (0.94–3.18) for diabetics carrying the CC genotype and 3.49 (2.22–5.49) for diabetics carrying the CT/TT genotype compared with non-diabetics carrying the CC genotype. Moreover, the SOD2 –1221G>A AA genotype carriers had a significantly increased risk for pancreatic cancer among those with a low dietary vitamin E intake but decreased risk among those with a high vitamin E intake (Pinteraction = 0.002). There was a non-significant interaction between diabetes and GSTA4 Ex5–64G>A genotypes (Pinteraction = 0.078). No significant interaction between genotype with cigarette smoking or vitamin C intake was observed. These data suggest that genetic variations in antioxidant defenses modify the risk of pancreatic cancer in diabetics or individuals with a low dietary vitamin E intake.

  X Dong and M. A. Simon
 

This study aimed to examine gender differences in social support and risk of elder mistreatment (EM) in a community-dwelling Chinese population. The authors conducted a cross-sectional study of 141 women and 270 men aged 60 years or above. EM was assessed using the modified Vulnerability to Abuse Screening Scale (VASS), and social support was measured using the Social Support Index (SSI). After adjusting for sociodemographic factors, socioeconomic status, depression, loneliness, and medical conditions, lower levels of social support were associated with an increased odds of EM in men (odds ratio [OR] = 5.35, 95% confidence interval [CI] = 2.18-13.15, p < .001) and in women (OR = 5.39, 95% CI = 1.95-14.85, p < .001). Perceived social support, but not instrumental social support, was associated with increased odds of EM in men and women. These findings could have important implication for health care professional and social services agencies in the detection, management, and prevention of EM among the aging Chinese population.

  Z Huang , M Chen , K Li , X Dong , J Han and Q. Zhang
 

Cryo-electron tomography was employed to reconstruct the structure of Chlamydia trachomatis. Results revealed that the features of the structures, especially those of the membranes, were preserved much better than those by conventional ultrathin section methods. This method also enabled us to determine that the thickness of the outer membrane of the elementary bodies is nearly twice of that of the reticulate bodies. Our observations give a clue to the mechanism of outer membrane changes.

  X Dong , C Yu , O Shynlova , J. R. G Challis , P. S Rennie and S. J. Lye
 

The progesterone receptor (PR) plays important roles in the establishment and maintenance of pregnancy. By dynamic interactions with coregulators, PR represses the expression of genes that increase the contractile activity of myometrium and contribute to the initiation of labor. We have previously shown that PTB-associated RNA splicing factor (PSF) can function as a PR corepressor. In this report, we demonstrated that the PSF heterodimer partner, p54nrb (non-POU-domain-containing, octamer binding protein), can also function as a transcription corepressor, independent of PSF. p54nrb Interacts directly with PR independent of progesterone. In contrast to PSF, p54nrb neither enhances PR protein degradation nor blocks PR binding to DNA. Rather, p54nrb recruits mSin3A through its N terminus to the PR-DNA complex, resulting in an inhibition of PR-mediated transactivation of the progesterone-response element-luciferase reporter gene. PR also repressed transcription of the connexin 43 gene (Gja1), an effect dependent on the presence of an activator protein 1 site within the proximal Gja1 promoter. Mutation of this site abolished PR-mediated repression and decreased the recruitment of PR and p54nrb onto the Gja1 promoter. Furthermore, knockdown p54nrb expression by small interfering RNA alleviated PR-mediated repression on Gja1 transcription, whereas overexpression of p54nrb enhanced it. In the physiological context of pregnancy, p54nrb protein levels decrease with the approach of labor in the rat myometrium. We conclude that p54nrb is a transcriptional corepressor of PR. Decreased expression of p54nrb at the time of labor may act to derepress PR-mediated inhibition on connexin 43 expression and contribute to the initiation of labor.

 
 
 
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