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Articles by S.Z. Raihan
Total Records ( 5 ) for S.Z. Raihan
  S.K. Biswas , A. Chowdhury , S.Z. Raihan , M.A. Muhit , M.A. Akbar and R. Mowla
  Kalanchoe pinnata is used in traditional medicines for the treatment of several health problems in Bangladesh. The study was designed to investigate the cytotoxicity and antibacterial activities of the chloroform extract of the leaves of Kalanchoe pinnata. Qualitative phytochemical analysis was also performed for the identification of several phytochemical compounds such as alkaloids, glycosides, steroids, gums, flavonoids, saponins, reducing sugar, tannins and terpenoids. The study revealed that the plant extract contained all of the phytoconstituents except steroids, flavonoids and terpenoids. The agar disc diffusion technique was used to investigate the antibacterial activities of the plant extract at 500 μg disc-1 against eight bacterial strains. The plant extract showed very low antibacterial activities with zone of inhibition ranging from 0.33±0.02 to 1.67±0.02 mm, while the maximum antibacterial action was recorded against E. coli with zone of inhibition of 1.67±0.02 mm but no sensitivity was found against V. cholerae. The antibacterial activity of the plant extract was compared with the standard drug, Levofloxacin which was used at 10 μg disc-1. Brine shrimp lethality bioassay was also done to find out the cytotoxic activity of the plant sample. The chloroform extract of the plant showed lethality against the brine shrimp nauplii (LC50: 125.89 and LC90: 234.42 μg mL-1. Finally, it was concluded that the chloroform extract of the plant leaves possessed considerable cytotoxic activity with less antibacterial potentials.
  S.K. Biswas , A. Chowdhury , J. Das , A. Chowdhury , S.Z. Raihan and M.A. Muhit
  The present study was designed to detect the presence of phytochemical compounds and to evaluate the cytotoxic profiles and antibacterial activities of the ethanol extract of the leaves of Elaeocarpus serratus. The phytochemical investigation was done according to the standard procedures. The phytochemical analysis of the extract showed the presence of alkaloid, glycoside, tannin, saponin, flavonoid and carbohydrate. The antibacterial tests of the plant extract and the standard drug, Levofloxacin were conducted against eight bacterial strains using agar disc diffusion technique. The extract at 500 μg disc-1 produced significant zone of inhibition against Bacillus subtilis (25.82±0.61mm), Bacillus megaterium (30.52±0.43 mm), Pseudomonas aeruginosa (20.35±0.51), Salmonella typhi (32.95±0.39 mm) and Vibrio cholerae (16.93±0.14) but no zone of inhibition was detected against Staphylococcus aureus, Escherichia coli and Shigella dysenteriae. The obtained results were also compared with the standard drug, Levofloxacin used at the concentration of 10 μg disc-1. Subsequently, the cytotoxicity test of the plant sample was performed using brine shrimp lethality bioassay which showed lethality against the brine shrimp nauplii with LC50 141.25 and LC90 870.96 μg mL-1. Finally, it was concluded that the ethanol extract of the leaves of Elaeocarpus serratus possessed significant antibacterial and cytotoxic properties.
  U.K. Karmakar , S.K. Biswas , A. Chowdhury , S.Z. Raihan , M.A. Akbar , M.A. Muhit and R. Mowla
  The ethanol extract of Asparagus racemosus Willd was examined for antbacterial and antioxidant properties. Phytochemical investigation was also done to identify the presence of phytochemical compounds. The ethanol extract at the concentration of 500 μg disc-1 showed moderate antibacterial activity against Staphylococcus saprophyticus, Enterococcus faecalies, Streptococcus agalactiae and Escherichia coli with zone of inhibition of 7.77±0.37, 6.07±0.06, 10.10±0.11 and 6.00±0.04 mm, respectively while 250 μg disc-1 of the extract did not reveal any zone of inhibition against the tested bacterial strains. Antioxidant activity of the ethanol extract was determined according to their scavenging activity of the stable DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical and 10% H2SO4. In the qualitative antioxidant assay, the extract showed free radical scavenging properties. Preliminary phytochemical analysis of the plant extract showed the presence of alkaloids, tannins, saponins, glycosides, flavonoids and carbohydrates which could be responsible for antibacterial and antioxidant properties justifying the ethnomedicinal applications of Asparagus racemosus. Thus, further advanced research is necessary to isolate and characterize the chemical compounds responsible for the therapeutic activities of the plant.
  S.K. Biswas , A. Chowdhury , J. Das , U.K. Karmakar , S.Z. Raihan , A.C. Das , M.A. Hannan , M.A. Monsur Dinar , M.J. Hassan , M.I. Hossain and M.R. Farhad
  Cuscuta epithymum Murr. (Convolvulaceae) is found in Bangladesh and has been used in traditional medicine. The present study was designed to investigate the preliminary phytochemical screening, cytotoxicity and antibacterial activities of the methanol extract of the plant stem. The preliminary phytochemical analysis was performed on the basis of the standard procedures and thin layer chromatography to confirm the presence of chemical compounds in the methanol extract of the plant. The minimum inhibitory concentration and cytotoxic activities of the extract were carried out according to broth dilution assay and brine shrimp lethality bioassay, respectively. The results of preliminary phytochemical analysis showed the presence of flavonoid, glycoside, alkaloids, carbohydrates, saponins and steroids in the plant extract. In this study, the methanol extract was subjected to Thin Layer Chromatography (TLC) in order to detect the phytoconstituents present in the extract and the best result of TLC was obtained from the solvent system comprising of toluene and ethyl acetate at the ratio of 5.5:4.5 which identified the maximum number of spots. Moreover, the extract showed moderate antibacterial activities against Bacillus megaterium, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi with MIC values of 4.96±0.20, 3.03±0.16, 3.47±0.20 and 4.07±0.08 mg mL-1, respectively. The methanol extract showed lethality against brine shrimp nauplii (LC50: 36.31 μg mL-1 and LC90: 83.18 μg mL-1 ). The results indicated that the methanol extract of the stem of the plant possessed antibacterial and cytotoxic properties with several numbers of chemical compounds.
  S.Z. Raihan , M.M. Monir , P. Biswas , S.K. Biswas , A. Chowdhury , J. Das and A.C. Das
  Dalbergia spinosa Roxb. (Family: Fabaceae) has many traditional uses in Bangladesh. The crude methanol extract of the stem barks of D. spinosa Roxb. was investigated for possible antinociceptive activity using acetic acid induced writhing model in mice. Phytochemical analysis was also performed using standard procedures to detect the presence of phytochemicals in the crude plant extract. The study results showed 37.20% inhibition of writhings in the tested mice when methanol extracts were given intraperitoneally (i.p.) at the dose of 250 mg extract kg-1 b.wt. The maximum inhibition (40.01%) of nociception effect was achieved at 500 mg extract kg-1 b.wt., i.p. which was also compared with the antinociceptive activity of the standard drug, diclofenac sodium at the dose of 25 mg extract kg-1 b.wt. which produced 68.37% inhibition of nociception effect. The inhibition of writhings was calculated in respective to control group and it was found that p-values (<0.0001) calculated by student’s t-test were statistically significant. However, the phytochemical screening revealed the presence of alkaloid, steroid, flavonoid, tannin, reducing sugar and gum. Finally, it can be concluded that crude methanol extracts of D. spinosa stem barks contain biologically active phytoconstituents exhibiting significant dose-dependent antinociceptive activity in the mice model used. Thus, it is recommended to isolate and characterize the compounds for the development of new analgesics.
 
 
 
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