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Articles by S.O. Asagba
Total Records ( 3 ) for S.O. Asagba
  S.O. Akporido and S.O. Asagba
  Oil pollution is a topical issue in Nigeria and other parts of the world and this is especially so where oil prospecting and processing takes place because of its adverse effect on human and animal health. It became necessary to carry out an environmental audit of the soils of an area suspected of receiving oil pollutants from a lubricating oil factory , this is especially so when oily material are mixed with soil and this is visible. Soil samples were collected from five sampling stations and two control sampling stations (These were collected so as to act as background values with which comparison could be made). These were analyzed for heavy metals by flame absorption spectroscopy after digestion with 2 M HNO3, Total Organic Extract (TOE) and Total Petroleum Hydrocarbons (TPH) by gravimetric method after extraction with methanol followed by hexane and the physicochemical parameters by standard methods. Important results include average values of pH (5.86±0.32), TOE (56300±19000 mg kg-1), TPH (38700±12000 mg kg-1), Zn (562±510 mg kg-1), Pb (227±160 mg kg-1), Cr (total) (94.5±150 mg kg-1), Cd (2.0±2.9 mg kg-1), total organic carbon (2.83±0.56%) and sand (91.7±1.3%) in the study area. The average concentrations of the pollutant parameters with the exception of Pb were higher in the study area than in the control area. The average concentrations of Cd, Zn, Pb and Cr exceeded guideline values with which they were compared. The average concentrations of TPH in the sampling stations exceeded Environmental Guideline and Standards for the petroleum industry in Nigeria soil/sediment intervention value for mineral oil (5000 mg kg-1). The average pH of the sampling stations fell below guideline range of the Canadian Soil Quality Guidelines (SQGs) with which they were compared. The results confirmed that the soils of the study area are heavily polluted with petroleum hydrocarbons and heavy metals.
  G.E. Eriyamremu , S.O. Asagba , V.E. Osagie , S.I. Ojeaburu and O. Lolodi
  This study reports the effect of unripe pawpaw and/or unripe plantain extracts on the phospholipid profile of the stomach and duodenum of normal rabbits. Supplementation of chow with unripe pawpaw or plantain extract significantly reduced (p<0.05) the weight gained by rabbits compared with the control. The total phospholipids content in the stomach and duodenum were significantly increased (p<0.05) in the test groups compared to the control. In the stomach and duodenum, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SGM) were significantly increased (p<0.05) in the test groups compared to the control. Pawpaw occasioned a decrease in the PE/PC ratio in both tissues as against an increase observed in the SGM/PC ratio. The results presented suggests that unripe pawpaw meal and unripe plantain extract alter the phospholipid profile of the stomach and duodenum in ways which may affect membrane fluidity of these tissues and would have profound effect on the gastro-duodenal mucosa and thus have implication(s) for gastric and duodenal ulcers in rabbits.
  S.O. Asagba , G.E. Eriyamremu , B.O. George and I. Okoro
  The present study highlights the potential of using lactate dehydrogenase (LDH, EC. 1.1.1.27) and aldehyde oxidase (AO, E.C.1.2.3.1.) activities and level of lipid peroxidation (LPO) in RBC as indices in monitoring the severity of P. falciparum malaria infections. Two hundred and forty one male patients from two major hospitals in Benin-City, Nigeria, with a history of malaria and confirmed to be infected with the P. falciparum malaria parasites by microscopic examination of Giemsa-stained thin blood slides were chosen for the study. These patients who fell within the 18-40 year age group were further grouped into low, moderate and high parasitemia based on the parasite density. A control group of healthy male adults in the same age range with the patients were also used for the study. Erythrocyte obtained from venous blood collected in heparinized tube after several centrifugations and appropriate washings with specified buffer solutions were assayed. The level of LPO in Infected Red Blood Cells (IRBC) was significantly higher (p<0.05) as compared to control with the level increasing with severity of malaria infection. Conversely, the LDH activity of IRBC was significantly (p<0.05) decreased relative to control and the decrease was also in the order of severity of the infection. However, no significant difference was observed in the AO activity in the different experimental groups. A significant (p<0.0001) negative correlation (r = - 0.9516) was observed between LDH activity and level of LPO. The results obtained suggest that LDH and LPO can be utilised as markers of malaria severity.
 
 
 
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