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Journal of Biological Sciences
Year: 2007  |  Volume: 7  |  Issue: 3  |  Page No.: 526 - 531

Colonic Lipid Peroxidation, Nuclear Membrane ATPase and Stress Enzymes in Rats Fed a Nigerian-Like Diet and Cycas

G.E. Eriyamremu, S.O. Asagba, S.O. Uanseoje, S.E. Omeregie and C.O. Omofoma    

Abstract: The purpose of the present study was to evaluate the effect of Nigerian-Like Diet (NLD) and Western-Like Diets (WLD) on colonic mucosa lipid peroxidation, stress enzymes and nuclear membrane ATPase in the early stages of colon carcinogenesis in rats. Sixty male Wistar rats were grouped into three groups of 20 animals each; one group was fed with a Normal Diet (ND) and acted as the diet control. One group was fed with the NLD and the last group was fed with a WLD for 12 weeks. In each diet class, half of the animals were fed with the diet alone and the other half was fed with the diet containing cycas and after six weeks, a mid term study was carried out. Mid-term and full-term studies show a significant (p< 0.05) increase in nuclear ATPase activity of the rats fed with the WLD and a decrease in those fed the NLD compared with control. Feeding rats with the NLD significantly (p< 0.05) decreased the level of colonic mucosa lipid peroxidation compared with the WLD. A significant rise in the activity of Superoxide Dismutase (SOD) was observed in the rats fed the ND and NLD, while in the rats fed the WLD, SOD activity was compromised in both the mid- and full-term studies. The study shows that a NLD and WLD fed to rats alter mucosa plasma membrane lipid peroxidation, SOD and nuclear membrane ATPase in ways which suggest that the NLD may protect rats from colon carcinogenesis.

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