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Articles by S.K. Verma
Total Records ( 5 ) for S.K. Verma
  Vartika Jain , S.K. Verma and S.S. Katewa
  Bombax ceiba Linn. (Silk cotton tree) is a well known ethno-medicinal plant employed to treat a wide variety of disorders in man and animals. In the present study, its root powder was evaluated for its effect on serum lipids, plasma fibrinolytic activity and antioxidant potential in individuals with stable Ischemic Heart Disease (IHD). Fifty patients of IHD were selected and randomly divided in two groups of twenty five each. Group I (treated group) received 1.5 g root powder twice daily for 12 weeks, while group II (placebo group) received matched placebo for similar duration. Blood samples were collected in fasting state initially and at an interval of six weeks, till the end of the study. Administration of 3 g B. ceiba root powder significantly (p<0.01) increased plasma fibrinolytic activity by 69.44% and serum total antioxidant status (p<0.05) by 106% at the end of the study. Furthermore, a significant decrease was observed in total cholesterol (p<0.01), triglycerides (p<0.05), Very Low Density Lipoprotein Cholesterol (VLDL-C) (p<0.05), Low Density Lipoprotein Cholesterol (LDL-C) (p<0.001) levels and Atherogenic Index (AI) (p<0.05) along with a significant rise in High Density Lipoprotein Cholesterol (HDL-C)/Low density lipoprotein cholesterol ratio (p<0.05) after 12 weeks of B. ceiba administration. In the placebo group, there were no significant alterations in any of the parameters at the end of study. The drug was tolerated well without any significant side effects. This study has first time scientifically validated the effect of B. ceiba root on modification of multiple coronary risk parameters in man.
  S.K. Verma , Vartika Jain and D.P. Singh
  The Indian Kudzu (Pueraria tuberosa DC.) is an important medicinal plant widely used in Indian and Chinese traditional systems of medicine. The present study is an attempt to evaluate effect of its tubers on blood pressure, coagulation parameters and antioxidant status in patients with stage 1 (primary) hypertension. In a long term, single blinded, placebo controlled study; 15 patients with stage 1 hypertension (group I), were administered 3 g P. tuberosa in two divided doses while another 15 patients (group II) were administered matched placebo for a period of twelve weeks. A significant fall of 25, 11 and 16 mmHg was observed in systolic (p<0.001), diastolic (p<0.05) and mean (p<0.001) blood pressure, respectively at the end of the study. Along with blood pressure reduction, there was a significant (p<0.01) reduction in plasma fibrinogen and significant enhancement of plasma fibrinolytic activity (p<0.001) and serum total antioxidant status (p<0.05). It was tolerated well without any untoward side effects.
  V. Jain , S.K. Verma , S.K. Sharma and S.S. Katewa
  Bombax ceiba Linn. (Red Silk Cotton Tree) commonly known as Semal tree; is a multipurpose tree species of tropical forests; providing food, fodder, fibre, fuel and medicine besides many ecological benefits. It is a dominant plant species of tropical dry deciduous forests of Southern Rajasthan, India. The present work is an attempt to justify the role of B. ceiba as an umbrella or life support tree for many animal species in forest areas of Southern Rajasthan. During the study period, total 43 animal species were observed who visited B. ceiba either for food, shelter or roosting purposes. Out of these, 29 species were from Avian fauna, 11 species belonged to Mammalia, two species belonged to Arthropoda and one from Reptilia. The present study confirms use of B. ceiba for balancing forest ecosystems and further recommends that this drought tolerant, easily propagable plant species should be planted in dotted fashion in forests specially in protected areas and also in home gardens as a keystone resource for many animal species.
  V. Jain , S.K. Verma , S.S. Katewa , S. Anandjiwala and B. Singh
  Silk cotton tree (Bombax ceiba Linn.) is a well known ethnomedicinal plant. Root of this plant was investigated for its antioxidant potential for the first time. Assessment of antioxidant activity was done using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay and Reducing power assay. Preliminary phytochemical screening of the roots showed presence of phenolics, tannins, flavonoids, steroids, saponins and cardiac glycosides. Methanolic extract of the roots showed high amount of phenolics (30.95% w/w) and tannins (15.45% w/w) and a very good DPPH radical scavenging activity (EC50 of 15.07 μg) in a dose dependent manner. The extract showed dose-dependent reduction ability (Fe3+ to Fe2+ transformation) with a maximum absorbance of 1.11 at a concentration of 500 μg of the extract. Acute study in healthy human volunteers showed a significant (p<0.05) rise in total antioxidant status at the end of 4 h after administration of 3 g root powder. This strong in vitro and in vivo antioxidant potential of B. ceiba dry root powder validates its uses in diabetes mellitus and heart disease as described in the traditional medicine.
  J. Scaria , S. Ramachandran , P.K. Jain and S.K. Verma
  A plasmid containing a transcriptional fusion between tetR regulated tet promoter from plasmid pOT182 and Enhanced Green Fluorescent Protein (EGFP) gene was created and was transformed into E. coli JM109 and this strain was used as whole cell bacterial biosensor for detection of tetracyclines in milk and water samples. The sensor strain E. coli JM109 (pJSKV41) was able to detect tetracycline in the range of 10-60 ng mL-1 sample and oxytetracycline in the range of 25-125 ng mL-1 of sample. When employed for detecting residual tetracyclines in pond water samples, the biosensor strain showed high sensitivity. Also the biosensor strain was able to detect residual tetracycline in goat milk even after 4 days of tetracycline treatment.
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