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Research Journal of Medicinal Plants
Year: 2011  |  Volume: 5  |  Issue: 4  |  Page No.: 462 - 470

Free Radical Scavenging Property of Bombax ceiba Linn. Root

V. Jain, S.K. Verma, S.S. Katewa, S. Anandjiwala and B. Singh    

Abstract: Silk cotton tree (Bombax ceiba Linn.) is a well known ethnomedicinal plant. Root of this plant was investigated for its antioxidant potential for the first time. Assessment of antioxidant activity was done using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay and Reducing power assay. Preliminary phytochemical screening of the roots showed presence of phenolics, tannins, flavonoids, steroids, saponins and cardiac glycosides. Methanolic extract of the roots showed high amount of phenolics (30.95% w/w) and tannins (15.45% w/w) and a very good DPPH radical scavenging activity (EC50 of 15.07 μg) in a dose dependent manner. The extract showed dose-dependent reduction ability (Fe3+ to Fe2+ transformation) with a maximum absorbance of 1.11 at a concentration of 500 μg of the extract. Acute study in healthy human volunteers showed a significant (p<0.05) rise in total antioxidant status at the end of 4 h after administration of 3 g root powder. This strong in vitro and in vivo antioxidant potential of B. ceiba dry root powder validates its uses in diabetes mellitus and heart disease as described in the traditional medicine.

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