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Articles by S.B. Mada
Total Records ( 4 ) for S.B. Mada
  S.B. Mada , A. Mohammed , A. Garba , H.A. Mohammed and I. Garba
  The present study was aimed to evaluate the stem bark aqueous extract of Psidium guajava for modulatory effect against CCl4 induced liver damage in rats. A total of thirty six male rats, were randomly divided into six groups of six rats each. The extract was administered orally for 15 days at 125, 250 and 500 mg kg-1 b.wt. The results obtained showed that treatment with the extract significantly (p<0.05) restored liver weight. There was significant (p<0.05) increase in the level of Packed Cell Volume (PCV), haemoglobin (Hb) and Red Blood Cell (RBC) counts and significant (p<0.05) decrease in White Blood Cell (WBC) counts compared to toxin control group. Also administration of the extract caused significant (p<0.05) decrease in the activities of Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) and the level of total bilirubin and significant (p<0.05) increase in total protein level compared to toxin control group. Similarly the extract caused a significant (p<0.05) increase in the activities of Catalase (CAT) and Superoxide Dismutase (SOD) and significant (p<0.05) decrease in reduced Glutathione (GSH) and Thiobarbituric Reactive Substances (TBARS) level compared to group 2 (toxin control group). The histopathological study indicated that treatment with the extract restored and regenerated hepatic cells compared to toxin control group. This study found that administration of aqueous stem bark extracts ameliorated hepatotoxicity induced by CCl4 in rats.
  A. Garba , S.B. Mada , G. Ibrahim , M.M. Abarshi , I.A. Dauran and A.B. Hamza
  The hepatoprotective effect of Ethyl Acetate Extract of Vitex doniana (EAEVD) stem bark on carbon tetrachloride (CCl4) induced hepatic damage was studied, to evaluate some biochemical parameters, to determine the in vitro antioxidant effect of the extract on Superoxide Dismutase (SOD), Catalase (CAT) glutathione peroxidase (GPX) and glutathione-s-transferase (GST) and to quantify the levels of some phytochemicals present in EAEVD stem bark. A total of twenty four Rats were used for the study. Animals in group1 served as vehicle control, Group 2 served as hepatotoxin (CCL4) treated group, Group 3 served as positive control (Sylimarin) treated group, Group 4 was administered with 100 (mg kg-1 b.wt.) of the extract and group 5 was administered with 200 (mg kg-1 b.wt.) of the extract After the experimental period of 14 days. The animals were sacrificed, blood and liver samples were collected and used for the evaluation of the following biochemical parameters Aspartate amino transferase (AST), Alanine amino transaminase (ALT) and Alkaline phosphatase (ALP) in serum, as well as thiobarbituric acidreactive substances (TBARS), lipidhydroperoxides superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPX) and glutathione-s-transferase (GST) in the liver. Administration of 100 and 200 mg kg-1 b.wt. (EAEVD) significantly decreased (p<0.05) AST, ALT, ALP TBARS and lipid hydroperoxides with a significant increase (p<0.05) in the levels of SOD, CAT, GPX and GST in in group 4 and 5. Twenty five mg kg-1 b.wt. sylimar in was used as standard, The results show that the oral administration of EAEVD plant prevents the progression of hepatic damage in Ccl4 treated wistar albino rats and suggest that the extract could be effective in the management of liver problems.
  A. Mohammed , S.B. Mada and H.M. Yakasai
  Senna siamea is a plant commonly used in traditional medicine to treat hypertension, malaria and diabetes mellitus. The aim of this study was to investigate the sub-chronic toxicity of aqueous extract from the stem bark of S. siamea male Wistar rats. The extract was orally administered for seven weeks at 200, 400, 800 and 1600 mg kg-1 body weight. The results obtained showed that the extract significantly (p<0.05) increases the body weight and feed intake of the rats. Hematological parameters (PCV, Hb, platelets, WBC and RBC) were not significantly (p<0.05) affected by the extract. But the levels of serum liver enzymes (Alkaline Phosphatase (ALP), Alanine Aminotransaminase (ALT), Aspartate Aminotransaminase (AST) were significantly different (p<0.05) from the normal control group. In contrast, no significant change was observed in the total protein and albumin levels in the treated group compared to the normal group. Similarly, serum glucose, triglycerides, cholesterol and the markers of kidney function (creatinine, urea, potassium, sodium and chloride) did not differ significantly (p<0.05) from the normal control group. The quantitative determination of saponins, alkaloids, total polyphenolics and flavonoids in (g/g) were found to be 0.07±0.01, 0.05±0.02, 0.92±0.05 and 0.06±0.01. These results may explain the use of S. siamea stem bark in folk medicine due its less toxic effect.
  A. Garba , S.B. Mada , G. Ibrahim , I.A. Dauran and A.B. Hamza
  The hypoglycemic and hypolipidemic effects of methanolic extract of Stachytarpheta angustifolia (MESA) were evaluated in Streptozotocin (STZ) induced diabetes in albino rats. The rats were treated with 1000 and 1300 mg kg-1 b.wt. (mg kg-1 b.wt.) of MESA for 28 days. The changes in body weight and fasting blood glucose level were measured in 5 days interval. After experimental period of 28 days, rats were sacrificed by cervical decapitation, blood sample was collected and the following biochemical parameters plasma glucose, total hemoglobin, glycosylated hemoglobin, Glucose 6 phosphatase (Glc 6-phosphatase), lipid Peroxides (LPO), triacylglycerols, cholesterol, LDL-cholesterol and HDL-cholesterol, were estimated. Administration of MESA to STZ-induced diabetic rats caused a significant decrease (p<0.05) in the levels of plasma glucose, glycosylated hemoglobin, Glc 6-phosphatase, LPO, triacylglycerols, cholesterol, LDL-cholesterol with a significant increase (p<0.05) in bodyweight, plasma insulin and HDL-cholesterol level Glibenclamide 600 μg kg-1 b.wt. was used as standard in this study. These results show that the oral administration of MESA plant prevents the progression of Diabetes-associated symptoms in STZ induced diabetic albino rats and suggest that MESA could be useful in the management of diabetes mellitus.
 
 
 
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