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Asian Journal of Biological Sciences
Year: 2013  |  Volume: 6  |  Issue: 3  |  Page No.: 161 - 167

Studies on Hypoglycemic and Hypolipidemic Effect of Methanolic Extract of Stachytarpheta angustifolia (Mill) Plant in Streptozotocin Induced Diabetic Rats

A. Garba, S.B. Mada, G. Ibrahim, I.A. Dauran and A.B. Hamza    

Abstract: The hypoglycemic and hypolipidemic effects of methanolic extract of Stachytarpheta angustifolia (MESA) were evaluated in Streptozotocin (STZ) induced diabetes in albino rats. The rats were treated with 1000 and 1300 mg kg-1 b.wt. (mg kg-1 b.wt.) of MESA for 28 days. The changes in body weight and fasting blood glucose level were measured in 5 days interval. After experimental period of 28 days, rats were sacrificed by cervical decapitation, blood sample was collected and the following biochemical parameters plasma glucose, total hemoglobin, glycosylated hemoglobin, Glucose 6 phosphatase (Glc 6-phosphatase), lipid Peroxides (LPO), triacylglycerols, cholesterol, LDL-cholesterol and HDL-cholesterol, were estimated. Administration of MESA to STZ-induced diabetic rats caused a significant decrease (p<0.05) in the levels of plasma glucose, glycosylated hemoglobin, Glc 6-phosphatase, LPO, triacylglycerols, cholesterol, LDL-cholesterol with a significant increase (p<0.05) in bodyweight, plasma insulin and HDL-cholesterol level Glibenclamide 600 μg kg-1 b.wt. was used as standard in this study. These results show that the oral administration of MESA plant prevents the progression of Diabetes-associated symptoms in STZ induced diabetic albino rats and suggest that MESA could be useful in the management of diabetes mellitus.

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