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by
S. Jyoti |
Total Records (
2 ) for
S. Jyoti |
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Y.H. Siddique
,
G. Ara
,
S. Jyoti
and
M. Afzal
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Parkinson’s Disease (PD) is characterized by the progressive loss of dopaminergic neurons. Drosophila mutants and transgenes have provided a platform to understand the mechanistic insight associated with the degenerative disease. In the present study, the effect of capsaicin was studied on the climbing ability of the PD model Drosophila expressing normal human alpha synuclein (h-αS) in the neurons. These flies exhibit locomotor dysfunction as the age progresses. Capsaicin at final concentration of 0.1, 0.5, 0.75 and 1.0 μL mL-1 was supplemented with the diet and the flies were allowed to feed for the 21 days. Capsaicin showed a dose dependent significant (p<0.05) delay in the loss of climbing ability of PD model flies as compared to the untreated PD flies. The results suggest that the capsaicin is potent in delaying the climbing disability of PD model flies and also supports the utility of this model in studying PD symptoms. |
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F. Naz
,
S. Jyoti
,
N. Akhtar
,
M. Afzal
and
Y.H. Siddique
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Oral Contraceptives (OCs) are the most popular type of birth
control pills. The study was designed to examine the biochemical changes which
occur due to the use of oral contraceptive pills (OCs). The study was based
on the questionnaire for having the information of any reproductive history
fasting, age, health, nature of menstrual cycle, bleeding, disease etc and blood
profiling for biochemical analysis of the women includes High Density Lipoprotein
Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), Total Cholesterol
(TC) and Triglycerides (TG). Lipid profiling was carried out by using a commercially
available diagnostic test kits. SPSS was used to analyze the data. The results
showed statistically significant differences among users of OCs compared to
non-users. Total cholesterol (242.92±2.842 mg dL-1), HDL-C
(58.65±1.098 mg dL-1), LDL-C (115.84±1.266 mg dL-1)
and triglycerides (105.56±2.341 mg dL-1) were significantly
higher compared to the Non-users (Total cholesterol 218.49±1.762, HDL-C
48.17±0.543, LDL-C 100.32±0.951 and triglycerides 83.77±2.299
mg dL-1). The result suggests that OCs increase the level of High
Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol
(LDL-C), Total Cholesterol (TC) and Triglycerides (TG). |
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