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American Journal of Drug Discovery and Development
Year: 2012  |  Volume: 2  |  Issue: 1  |  Page No.: 50 - 54

Effect of Capsaicin on the Climbing Ability in Drosophila Model of Parkinson’s Disease

Y.H. Siddique, G. Ara, S. Jyoti and M. Afzal    

Abstract: Parkinson’s Disease (PD) is characterized by the progressive loss of dopaminergic neurons. Drosophila mutants and transgenes have provided a platform to understand the mechanistic insight associated with the degenerative disease. In the present study, the effect of capsaicin was studied on the climbing ability of the PD model Drosophila expressing normal human alpha synuclein (h-αS) in the neurons. These flies exhibit locomotor dysfunction as the age progresses. Capsaicin at final concentration of 0.1, 0.5, 0.75 and 1.0 μL mL-1 was supplemented with the diet and the flies were allowed to feed for the 21 days. Capsaicin showed a dose dependent significant (p<0.05) delay in the loss of climbing ability of PD model flies as compared to the untreated PD flies. The results suggest that the capsaicin is potent in delaying the climbing disability of PD model flies and also supports the utility of this model in studying PD symptoms.

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