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The anticonvulsant effects of the crude flavonoid fraction
of the stem bark of Ficus sycomorus were studied using the subcutaneous
Pentylenetetrazole (PTZ) and Maximal Electroshock Test (MEST) models in
mice and chicks respectively. The crude flavonoid fraction exhibited a
significant (p<0.05) latency in mean onset and mean time of death of
convulsed animal with a 20% protection at a dose of 10 mg kg-1
body weight i.p. (comparable to Valproic acid at 200 mg kg-1)
while it showed a significant (p<0.05) and dose dependent maximal protection
(83.3%) in the Maximal Electroshock Test (MEST) at an optimal dose of
20 mg kg-1 body weight i.p. (comparable to Phenytoin at 20
mg kg-1). The results obtained supported the claim in the traditional
use of the stem bark of the plant in the management of epilepsy.
