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Journal of Pharmacology and Toxicology

Year: 2008  |  Volume: 3  |  Issue: 5  |  Page No.: 351 - 356

Anticonvulsant Activities of Crude Flavonoid Fraction of the Stem Bark of Ficus sycomorus (Moraceae)

G. Ibrahim, S. Abdulmumin, K.Y. Musa and A.H. Yaro

Abstract

The anticonvulsant effects of the crude flavonoid fraction of the stem bark of Ficus sycomorus were studied using the subcutaneous Pentylenetetrazole (PTZ) and Maximal Electroshock Test (MEST) models in mice and chicks respectively. The crude flavonoid fraction exhibited a significant (p<0.05) latency in mean onset and mean time of death of convulsed animal with a 20% protection at a dose of 10 mg kg-1 body weight i.p. (comparable to Valproic acid at 200 mg kg-1) while it showed a significant (p<0.05) and dose dependent maximal protection (83.3%) in the Maximal Electroshock Test (MEST) at an optimal dose of 20 mg kg-1 body weight i.p. (comparable to Phenytoin at 20 mg kg-1). The results obtained supported the claim in the traditional use of the stem bark of the plant in the management of epilepsy.

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