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Articles by Naznin Ara Khatune
Total Records ( 4 ) for Naznin Ara Khatune
  M. Zakir Sultan , Naznin Ara Khatune , Zakia Sultana Sathi , Md. Shah Alam Bhuiyan , M. Golam Sadik , M. Akteruzzaman Choudury , M. A. Gafur and Md. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml-1.
  Naznin Ara Khatune , Md. Ekramul Islam , Md. Aziz Abdur Rahman , Md. Asik Mosaddik and Md. Ekramul Haque
  The potential cytotoxic effect of a new benzofuran derivative, 4-hydroxy hexahydrobenzofuran-7-one isolated from Nyctanthes arbor-tristis Linn was evaluated on Ehrlich Ascite Carcinoma (EAC) cells in Swiss Albino mice. 4-Hydroxy hexahydrobenzofuran-7-one was administered in a daily dose of Bangladesh 20 mg kg-1 of mouse after inoculation of Ehrlich Ascite Carcinoma (EAC) cell to the mice. After 5 days, the growth inhibition of cell in percentage was determined in comparison with control mice and it was found that there was no significant difference between average no. of cells counted after treatment in mice receiving 4-hydroxy hexahydrobenzofuran-7- one and in control mice (2.15±0.031) x 107 vs (3.79±0.019) x107 cells, respectively. The compound inhibited the cell growth by 43.27% only. 4-Hydroxy hexahydrobenzofuran-7-one (20mg kg-1 mouse day-1) over 5 days had no significant cytotoxic effect in mice in dose of 20-mg kg-1 mouse for 5 days.
  A.K.M. Nasimul Islam , M. Abbas Ali , Abu Sayeed , Anwarul Islam , S.M. Kousik Arefin , Naznin Ara Khatune and G.R.M. Astaq Mohal Khan
  Barks of Caesalpinia pulcherrima yielded a glycoside, Lathyrol-3-phenylacetate-5,15-diacetate (CP-2). The compound, CP-2, showed significant antibacterial and antifungal effects. The minimum inhibitory concentration (MIC) of CP-2 against Bacillus cereus and Shigella dysenteriae was determined and the values were 64 and 32 μg ml-1, respectively. The cytotoxicity of CP-2 was determined by brine shrimp lethality bioassay and LC50 value was 5.39 μg ml-1. The mortality rate by the compound with highest concentration suggests the drug to be used at highest doses and also suitable for further clinical trial.
  Md. Ekramul Islam , Naznin Ara Khatune , M. I. I. Wahed , Md. Ekramul Haque and Md. Ashiik Mosaddik
  The isolated pure compound phenyl ethyl β-D glucopyranoside from the stem of the plant Sida rhombifolia was evaluated for larvicidal activity against common filaria vector, Culex quinquefasciatus at different instar under laboratory conditions. The LC values for the isolated compound was 36.22, 43.94 and 50 44.92, 58.34 and 60.40, 63.32 and 70.72, 82.52 ppm for 1st, 2nd, 3rd and 4th instar larvae Culex quinquefasciatus at 24 and 48 h post exposure, respectively.
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