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Journal of Medical Sciences

Year: 2003  |  Volume: 3  |  Issue: 2  |  Page No.: 169 - 173

In vivo Cytotoxic Evaluation of a New Benzofuran Derivative Isolated from Nyctanthes arbor-tristis L. on Ehrlich Ascite Carcinoma Cells (EAC) in Mice

Naznin Ara Khatune, Md. Ekramul Islam, Md. Aziz Abdur Rahman, Md. Asik Mosaddik and Md. Ekramul Haque

Abstract

The potential cytotoxic effect of a new benzofuran derivative, 4-hydroxy hexahydrobenzofuran-7-one isolated from Nyctanthes arbor-tristis Linn was evaluated on Ehrlich Ascite Carcinoma (EAC) cells in Swiss Albino mice. 4-Hydroxy hexahydrobenzofuran-7-one was administered in a daily dose of Bangladesh 20 mg kg-1 of mouse after inoculation of Ehrlich Ascite Carcinoma (EAC) cell to the mice. After 5 days, the growth inhibition of cell in percentage was determined in comparison with control mice and it was found that there was no significant difference between average no. of cells counted after treatment in mice receiving 4-hydroxy hexahydrobenzofuran-7- one and in control mice (2.15±0.031) x 107 vs (3.79±0.019) x107 cells, respectively. The compound inhibited the cell growth by 43.27% only. 4-Hydroxy hexahydrobenzofuran-7-one (20mg kg-1 mouse day-1) over 5 days had no significant cytotoxic effect in mice in dose of 20-mg kg-1 mouse for 5 days.

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